Compartmentalized Control of Skin Immunity by Resident Commensals

被引：644

作者：

Naik, Shruti ^{[1
,2
]}

Bouladoux, Nicolas ^{[1
]}

Wilhelm, Christoph ^{[1
]}

Molloy, Michael J. ^{[1
]}

Salcedo, Rosalba ^{[3
,4
]}

Kastenmuller, Wolfgang ^{[5
]}

Deming, Clayton ^{[6
]}

Quinones, Mariam ^{[7
]}

Koo, Lily ^{[8
]}

Conlan, Sean ^{[6
]}

Spencer, Sean ^{[1
,2
]}

Hall, Jason A. ^{[9
]}

Dzutsev, Amiran ^{[3
,4
]}

Kong, Heidi ^{[10
]}

Campbell, Daniel J. ^{[11
,12
]}

Trinchieri, Giorgio ^{[3
]}

Segre, Julia A. ^{[6
]}

Belkaid, Yasmine ^{[1
]}

机构：

[1] NIAID, Mucosal Immun Sect, Parasit Dis Lab, Bethesda, MD 20892 USA

[2] Univ Penn, Immunol Grad Grp, Philadelphia, PA 19104 USA

[3] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA

[4] NCI, SAIC Frederick Inc, Frederick, MD 21701 USA

[5] NIAID, Lymphocyte Biol Sect, Immunol Lab, Bethesda, MD 20892 USA

[6] NHGRI, Genet & Mol Biol Branch, Bethesda, MD 20892 USA

[7] NIAID, Bioinformat & Computat Biosci Branch, Bethesda, MD 20892 USA

[8] NIAID, Res Technol Branch, Bethesda, MD 20892 USA

[9] NYU, Sch Med, Skirball Inst Biomol Med, Kimmel Ctr Biol & Med,Mol Pathogenesis Program, New York, NY 10016 USA

[10] NCI, Dermatol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[11] Benaroya Res Inst, Seattle, WA 98101 USA

[12] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

来源：

SCIENCE | 2012年 / 337卷 / 6098期

关键词：

REGULATORY T-CELLS; HUMAN MICROBIOME; DENDRITIC CELLS; INNATE IMMUNITY; SYSTEM; RECOGNITION; DIVERSITY; INTESTINE; INFECTION; RESPONSES;

D O I：

10.1126/science.1225152

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intestinal commensal bacteria induce protective and regulatory responses that maintain host-microbial mutualism. However, the contribution of tissue-resident commensals to immunity and inflammation at other barrier sites has not been addressed. We found that in mice, the skin microbiota have an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte function. Protective immunity to a cutaneous pathogen was found to be critically dependent on the skin microbiota but not the gut microbiota. Furthermore, skin commensals tuned the function of local T cells in a manner dependent on signaling downstream of the interleukin-1 receptor. These findings underscore the importance of the microbiota as a distinctive feature of tissue compartmentalization, and provide insight into mechanisms of immune system regulation by resident commensal niches in health and disease.

引用

页码：1115 / 1119

页数：5

共 33 条

[1] A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity [J].

Belkaid, Y ;

Mendez, S ;

Lira, R ;

Kadambi, N ;

Milon, G ;

Sacks, D .

JOURNAL OF IMMUNOLOGY, 2000, 165 (02) :969-977

[2] CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].

Belkaid, Y ;

Piccirillo, CA ;

Mendez, S ;

Shevach, EM ;

Sacks, DL .

NATURE, 2002, 420 (6915) :502-507

[3]

Cebra JJ, 1999, AM J CLIN NUTR, V69, p1046S, DOI 10.1093/ajcn/69.5.1046s

[4] Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity [J].

Clarke, Thomas B. ;

Davis, Kimberly M. ;

Lysenko, Elena S. ;

Zhou, Alice Y. ;

Yu, Yimin ;

Weiser, Jeffrey N. .

NATURE MEDICINE, 2010, 16 (02) :228-U137

[5] Bacterial Community Variation in Human Body Habitats Across Space and Time [J].

Costello, Elizabeth K. ;

Lauber, Christian L. ;

Hamady, Micah ;

Fierer, Noah ;

Gordon, Jeffrey I. ;

Knight, Rob .

SCIENCE, 2009, 326 (5960) :1694-1697

[6]

de Oliveira M R, 1999, Rev Inst Med Trop Sao Paulo, V41, P87

[7] Microbial Symbiosis with the Innate Immune Defense System of the Skin [J].

Gallo, Richard L. ;

Nakatsuji, Teruaki .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (10) :1974-1980

[8] The skin microbiome [J].

Grice, Elizabeth A. ;

Segre, Julia A. .

NATURE REVIEWS MICROBIOLOGY, 2011, 9 (04) :244-253

[9] Topographical and Temporal Diversity of the Human Skin Microbiome [J].

Grice, Elizabeth A. ;

Kong, Heidi H. ;

Conlan, Sean ;

Deming, Clayton B. ;

Davis, Joie ;

Young, Alice C. ;

Bouffard, Gerard G. ;

Blakesley, Robert W. ;

Murray, Patrick R. ;

Green, Eric D. ;

Turner, Maria L. ;

Segre, Julia A. .

SCIENCE, 2009, 324 (5931) :1190-1192

[10] Skin-draining lymph nodes contain dermis-derived CD103- dendritic cells that constitutively produce retinoic acid and induce Foxp3+ regulatory T cells [J].

Guilliams, Martin ;

Crozat, Karine ;

Henri, Sandrine ;

Tamoutounour, Samira ;

Grenot, Pierre ;

Devilard, Elisabeth ;

de Bovis, Beatrice ;

Alexopoulou, Lena ;

Dalod, Marc ;

Malissen, Bernard .

BLOOD, 2010, 115 (10) :1958-1968

← 1 2 3 4 →