New perspectives on nuclear transport

被引:54
作者
Komeili, A [1 ]
O'Shea, EK [1 ]
机构
[1] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USA
关键词
nuclear import; nuclear export; import receptor; export receptor; RNA transport;
D O I
10.1146/annurev.genet.35.102401.090720
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A central aspect of cellular function is the proper regulation of nucleocytoplasmic transport. In recent years, significant progress has been made in identifying and characterizing the essential components of the transport machinery. Despite these advances, some facets of this process are still unclear. Furthermore, recent work has uncovered novel molecules and mechanisms of nuclear transport. This review focuses on the unresolved and novel aspects of nuclear transport and explores issues in tRNA, snRNA, and mRNA export that highlight the diversity of nuclear transport mechanisms.
引用
收藏
页码:341 / 364
页数:24
相关论文
共 99 条
[1]   IDENTIFICATION OF CYTOSOLIC FACTORS REQUIRED FOR NUCLEAR LOCATION SEQUENCE-MEDIATED BINDING TO THE NUCLEAR-ENVELOPE [J].
ADAM, EJH ;
ADAM, SA .
JOURNAL OF CELL BIOLOGY, 1994, 125 (03) :547-555
[2]   NUCLEAR-PROTEIN IMPORT IN PERMEABILIZED MAMMALIAN-CELLS REQUIRES SOLUBLE CYTOPLASMIC FACTORS [J].
ADAM, SA ;
MARR, RS ;
GERACE, L .
JOURNAL OF CELL BIOLOGY, 1990, 111 (03) :807-816
[3]   The role of exportin-t in selective nuclear export of mature tRNAs [J].
Arts, GJ ;
Kuersten, S ;
Romby, P ;
Ehresmann, B ;
Mattaj, IW .
EMBO JOURNAL, 1998, 17 (24) :7430-7441
[4]   CATALYSIS OF GUANINE-NUCLEOTIDE EXCHANGE ON RAN BY THE MITOTIC REGULATOR RCC1 [J].
BISCHOFF, FR ;
PONSTINGL, H .
NATURE, 1991, 354 (6348) :80-82
[5]   RANGAP1 INDUCED GTPASE ACTIVITY OF NUCLEAR RAS-RELATED RAN [J].
BISCHOFF, FR ;
KLEBE, C ;
KRETSCHMER, J ;
WITTINGHOFER, A ;
PONSTINGL, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) :2587-2591
[6]   HUMAN RANGTPASE-ACTIVATING PROTEIN RANGAP1 IS A HOMOLOG OF YEAST RNA1P INVOLVED IN MESSENGER-RNA PROCESSING AND TRANSPORT [J].
BISCHOFF, FR ;
KREBBER, H ;
KEMPF, T ;
HERMES, I ;
PONSTINGL, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1749-1753
[7]   RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors [J].
Bischoff, FR ;
Görlich, D .
FEBS LETTERS, 1997, 419 (2-3) :249-254
[8]   Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p [J].
Blondel, M ;
Alepuz, PM ;
Huang, LS ;
Shaham, S ;
Ammerer, G ;
Peter, M .
GENES & DEVELOPMENT, 1999, 13 (17) :2284-2300
[9]   A Ran-independent pathway for export of spliced mRNA [J].
Clouse, KN ;
Luo, MJ ;
Zhou, ZL ;
Reed, R .
NATURE CELL BIOLOGY, 2001, 3 (01) :97-99
[10]   Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex [J].
Damelin, M ;
Silver, PA .
MOLECULAR CELL, 2000, 5 (01) :133-140