Can Intratympanic Dexamethasone Added to Systemic Steroids Improve Hearing Outcome in Patients With Sudden Deafness?

被引：96

作者：

Ahn, Joong Ho ^{[1
]}

Yoo, Myung Hoon ^{[1
]}

Yoon, Tae Hyun ^{[1
]}

Chung, Jong Woo ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol, Seoul 138736, South Korea

来源：

LARYNGOSCOPE | 2008年 / 118卷 / 02期

关键词：

Sudden sensorineural hearing loss; dexamethasone; tympanum; injection;

D O I：

10.1097/MLG.0b013e3181585428

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: To evaluate the therapeutic efficacy of intratympanic dexamethasone (ITD) injections added to systemic steroids in patients with idiopathic sudden sensorineural healing loss (HL). Materials and Methods: A total of 120 patients diagnosed with sudden HL were treated with ITD injections (0.3 mL on days 1, 3, and 5) plus 48 mg methylprednisolone (ITD group) or methylprednisolone alone (control group). Results: The total recovery rate after the treatment was 73.3% in the ITD group and 70.0% in the control group. Although improvements in pure-tone average were the same in the two groups, the ITD group showed significantly better hearing improvement at 250 Hz than the control group. Conclusion: The addition of ITD to systemic steroids did not result in significant improvements in the treatment of idiopathic sudden HL.

引用

页码：279 / 282

页数：4

共 19 条

[1] Titration streptomycin therapy in Meniere's disease: Long-term results [J].

Balyan, FR ;

Taibah, A ;

De Donato, G ;

Aslan, A ;

Falcioni, M ;

Russo, A ;

Sanna, M .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1998, 118 (02) :261-266

[2] Intratympanic dexamethasone for sudden sensorineural hearing loss: Clinical and laboratory evaluation [J].

Chandrasekhar, SS .

OTOLOGY & NEUROTOLOGY, 2001, 22 (01) :18-23

[3] Intratympanic dexamethasone injection for refractory sudden sensorineural hearing loss [J].

Choung, YH ;

Park, K ;

Shin, YR ;

Cho, MJ .

LARYNGOSCOPE, 2006, 116 (05) :747-752

[4] Distribution of Na,K-ATPase is normal in the inner ear of a mouse with a null mutation of the glucocorticoid receptor [J].

Erichsen, S ;

Stierna, P ;

Bagger-Sjöbäck, D ;

Curtis, LM ;

Rarey, KE ;

Schmid, W ;

Hultcrantz, M .

HEARING RESEARCH, 1998, 124 (1-2) :146-154

[5] Intratympanic steroids for idiopathic sudden sensorineural hearing loss [J].

Fitzgerald, Dennis C. ;

McGuire, John F. .

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2007, 116 (04) :253-256

[6] Intratympanic steroid perfusion for refractory sudden sensorineural hearing loss [J].

Herr, BD ;

Marzo, SJ .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2005, 132 (04) :527-531

[7] Round window gentamicin application: an inner ear hair cell damage protocol for the mouse [J].

Heydt, JL ;

Cunningham, LL ;

Rubel, EW ;

Coltrera, MD .

HEARING RESEARCH, 2004, 192 (1-2) :65-74

[8] Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig [J].

Himeno, C ;

Komeda, M ;

Izumikawa, M ;

Takemura, K ;

Yagi, M ;

Yang, WP ;

Doi, T ;

Kuriyama, H ;

Miller, JM ;

Yamashita, T .

HEARING RESEARCH, 2002, 167 (1-2) :61-70

[9] Comparison of intratympanic and intravenous dexamethasone treatment on sudden sensorineural hearing loss with diabetes [J].

Kakehata, Seiji ;

Sasaki, Akira ;

Oji, Kasumi ;

Futai, Kazunori ;

Ota, TShuji ;

Makinae, Tkirnitoshi ;

Shinkawa, Hideichi .

OTOLOGY & NEUROTOLOGY, 2006, 27 (05) :604-608

[10] Intratympanic methylprednisolone for sudden sensorineural hearing loss [J].

Kilic, Rahmi ;

Safak, Mustafa Asim ;

Oguz, Haldun ;

Kargin, Selda ;

Demirci, Munir ;

Samim, Erdal ;

Ozluoglu, Levent Naci .

OTOLOGY & NEUROTOLOGY, 2007, 28 (03) :312-316

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