学术探索
学术期刊
新闻热点
数据分析
智能评审

The cytochrome P450 3A4 inducer metyrapone is an activator of the human pregnane X receptor

被引：12
作者：
Wright, MC [1 ]
机构：
[1] Southampton Gen Hosp, Southampton SO16 6YD, Hants, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 1999年 / 27卷 / 04期
关键词：
D O I：
10.1042/bst0270387
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：387 / 391
页数：5
相关论文
共 30 条
  • [1] AOYAMA T, 1989, J BIOL CHEM, V264, P10388
  • [2] Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: Regulation by activator protein-1 DNA binding proteins
    Bahr, MJ
    Vincent, KJ
    Arthur, MJP
    Fowler, AV
    Smart, DE
    Wright, MC
    Clark, IM
    Benyon, RC
    Iredale, JP
    Mann, DA
    [J]. HEPATOLOGY, 1999, 29 (03) : 839 - 848
  • [3] Barwick JL, 1996, MOL PHARMACOL, V50, P10
  • [4] SXR, a novel steroid and xenobiotic-sensing nuclear receptor
    Blumberg, B
    Sabbagh, W
    Juguilon, H
    Bolado, J
    van Meter, CM
    Ono, ES
    Evans, RM
    [J]. GENES & DEVELOPMENT, 1998, 12 (20) : 3195 - 3205
  • [5] Orphan nuclear receptors - new ligands and new possibilities
    Blumberg, B
    Evans, RM
    [J]. GENES & DEVELOPMENT, 1998, 12 (20) : 3149 - 3155
  • [6] The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor
    Calleja, C
    Pascussi, JM
    Mani, JC
    Maurel, P
    Vilarem, MJ
    [J]. NATURE MEDICINE, 1998, 4 (01) : 92 - 96
  • [7] Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans
    Edwards, RJ
    Adams, DA
    Watts, PS
    Davies, DS
    Boobis, AR
    [J]. BIOCHEMICAL PHARMACOLOGY, 1998, 56 (03) : 377 - 387
  • [8] HOSTETLER KA, 1989, MOL PHARMACOL, V35, P279
  • [9] BIPHASIC REGULATION OF CYTOCHROME-P450 2B1/2 MESSENGER-RNA EXPRESSION BY DEXAMETHASONE IN PRIMARY CULTURES OF ADULT-RAT HEPATOCYTES MAINTAINED ON MATRIGEL
    KOCAREK, TA
    SCHUETZ, EG
    GUZELIAN, PS
    [J]. BIOCHEMICAL PHARMACOLOGY, 1994, 48 (09) : 1815 - 1822
  • [10] The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    Lehmann, JM
    McKee, DD
    Watson, MA
    Willson, TM
    Moore, JT
    Kliewer, SA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (05) : 1016 - 1023
123