Role of skeletal muscle proteoglycans during myogenesis

被引:64
作者
Brandan, Enrique [1 ]
Gutierrez, Jaime [1 ]
机构
[1] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Biol Celular & Mol, Ctr Envejecimiento & Regenerac,CARE, Santiago, Chile
关键词
Proteoglycans; Skeletal muscle formation; Growth factors; Muscular diseases; Fibrosis; FIBROBLAST-GROWTH-FACTOR; HEPARAN-SULFATE PROTEOGLYCANS; LEUCINE-RICH PROTEOGLYCANS; DUCHENNE MUSCULAR-DYSTROPHY; FACTOR-DEPENDENT MECHANISM; HEPATIC STELLATE CELLS; FACTOR SCATTER FACTOR; EXTRACELLULAR-MATRIX; MYOBLAST DIFFERENTIATION; ACETYLCHOLINE-RECEPTOR;
D O I
10.1016/j.matbio.2013.03.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Skeletal muscle formation during development and the adult mammal consists of a highly organised and regulated the sequence of cellular processes intending to form or repair muscle tissue. This sequence includes, cell proliferation, migration, and differentiation. Proteoglycans (PGs), macromolecules formed by a core protein and glycosaminoglycan chains (GAGS) present a great diversity of functions explained by their capacity to interact with different ligands and receptors forming part of their signalling complex and/or protecting them from proteolytic cleavage. Particularly attractive is the function of the different types of PGs present at the neuromuscular junction (NMJ). This review is focussed on the advances reached to understand the role of PGs during myogenesis and skeletal muscular dystrophies. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:289 / 297
页数:9
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