Cancer vaccination: Manipulation of immune responses at old age

被引：9

作者：

Gravekamp, Claudia ^{[1
]}

Kim, Sun Hee ^{[1
]}

Castro, Francisco ^{[1
]}

机构：

[1] Calif Pacific Med Ctr, Res Inst, San Francisco, CA 94107 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2009年 / 130卷 / 1-2期

关键词：

Cancer vaccines; Immunotherapy; Impaired T-cell responses; Aging; REGULATORY T-CELLS; HUMAN PERIPHERAL-BLOOD; KAPPA-B ACTIVATION; BREAST-TUMOR MODEL; CLASS-I EXPRESSION; DENDRITIC CELLS; ANTITUMOR-ACTIVITY; MAGE-B; RECEPTOR; VACCINES;

D O I：

10.1016/j.mad.2008.05.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The incidence of cancer has increased over the last decade, mainly due to ail increase in the elderly Population. Vaccine therapy for cancer is less toxic than chemotherapy or radiation and Could be, therefore, especially effective in older, more frail cancer patients. However. it has been shown that older individuals do not respond to vaccine therapy as well as younger adults. This has been attributed to T-cell unresponsiveness, a phenomenon also observed in cancer patients per se. This review Summarizes the current knowledge of impaired T-cell responses in cancer patients and the elderly, and the results Of cancer vaccination in preclinical models at young and old age. Finally. Various approaches how to manipulate immune responses against cancer by vaccination at older age will be proposed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：67 / 75

页数：9

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