Correlation between synovial fluid and serum IL-1β levels after ACL surgery-preliminary report

被引:36
作者
Darabos, Nikica [1 ]
Hundric-Haspl, Zeljka [2 ]
Haspl, Miroslav [3 ]
Markotic, Alemka [4 ]
Darabos, Anela [5 ]
Moser, Carsten [6 ]
机构
[1] Gen Hosp Varazdin, Dept Gen Surg & Traumatol, Varazhdin 42000, Croatia
[2] Croatian Inst Transfus Med, Zagreb 10000, Croatia
[3] Univ Zagreb, Sch Med, Dept Orthopaed Surg, Zagreb 10000, Croatia
[4] Univ Hosp Infect Dis, Sci Unit, Zagreb 10000, Croatia
[5] Gen Hosp Varazdin, Sci Unit, Varazhdin 42000, Croatia
[6] Ctr Mol Orthopaed, D-40212 Dusseldorf, Germany
关键词
INTERLEUKIN-1 RECEPTOR ANTAGONIST; CRUCIATE LIGAMENT RECONSTRUCTION; TUNNEL ENLARGEMENT; BONE; CYTOKINES; TENDON; KNEE; MECHANISMS; BLOOD;
D O I
10.1007/s00264-008-0649-1
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
100224 [整形外科学];
摘要
The possibility of controlling the harmful intra-articular influence of elevated interleukin (IL)-1 beta synovial fluid concentration after anterior cruciate ligament (ACL) surgery could be useful. We investigated the correlation between serum and synovial fluid IL-1 beta levels following ACL reconstruction. We measured IL-1 beta concentration periodically in three synovial fluid and four serum samples in each of 20 patients receiving either autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and several growth factors (group A) or placebo (group B). A decrease in IL-1 beta synovial fluid concentration appeared to be more pronounced in absolute terms in group A. In eight patients serum IL-1 beta was detected on the 6th postoperative day. In four of them whose synovial fluid levels were over 10 pg/ml on the 6th postoperative day, serum IL-1 beta was detected on the 10th postoperative day. The results were different in group B. Correlation between serum and synovial fluid IL-1 beta appearance persists in patients after ACL surgery and ACS application. This study is an example of ACS influence on the ACL healing process controlling the IL-1 beta levels on the basis of the serum IL-1 beta detection.
引用
收藏
页码:413 / 418
页数:6
相关论文
共 25 条
[1]
INTERLEUKIN-1 RECEPTOR ANTAGONIST [J].
AREND, WP .
ADVANCES IN IMMUNOLOGY, VOL 54, 1993, 54 :167-227
[2]
Berg EE, 2001, ARTHROSCOPY, V17, P189, DOI 10.1053/jars.2001.20958
[3]
Biological mechanisms of bone and cartilage remodelling-genomic perspective [J].
Borovecki, F. ;
Pecina-Slaus, N. ;
Vukicevic, S. .
INTERNATIONAL ORTHOPAEDICS, 2007, 31 (06) :799-805
[4]
The natural history of the anterior cruciate ligament-deficient knee - Changes in synovial fluid cytokine and keratan sulfate concentrations [J].
Cameron, M ;
Buchgraber, A ;
Passler, H ;
Vogt, M ;
Thonar, E ;
Fu, F ;
Evans, CH .
AMERICAN JOURNAL OF SPORTS MEDICINE, 1997, 25 (06) :751-754
[5]
Cameron M L, 1994, Knee Surg Sports Traumatol Arthrosc, V2, P38, DOI 10.1007/BF01552652
[6]
The role of the interleukin-1 receptor antagonist in blocking inflammation mediated by interleukin-1 [J].
Dinarello, CA .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (10) :732-734
[7]
[8]
THE INTERLEUKIN-1 FAMILY - 10 YEARS OF DISCOVERY [J].
DINARELLO, CA .
FASEB JOURNAL, 1994, 8 (15) :1314-1325
[9]
In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints -: Prevention of osteoarthritis progression [J].
Fernandes, J ;
Tardif, G ;
Martel-Pelletier, J ;
Lascau-Coman, V ;
Dupuis, M ;
Moldovan, F ;
Sheppard, M ;
Krishnan, BR ;
Pelletier, JP .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (04) :1159-1169
[10]
FRANK C, 1985, CLIN ORTHOP RELAT R, P15