One-pot synthesis of 1,2,4-oxadiazoles from carboxylic acid esters and amidoximes using potassium carbonate

被引：58

作者：

Amarasinghe, Kande K. D.

Maier, Matthew B.

Srivastava, Anil

Gray, Jeffrey L.

机构：

[1] Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA

[2] Chembiotek Res Int, Kolkata 700091, W Bengal, India

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 22期

关键词：

oxadiazoles; amidoximes; potassium carbonate; cyclodehydration;

D O I：

10.1016/j.tetlet.2006.03.155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient one-pot synthesis of 1,2,4-oxadiazoles is described. The condensation of carboxylic acid esters and amidoximes in the presence of potassium carbonate was employed to synthesize a variety of mono-, bis- and tris-oxadiazoles in moderate to excellent yields. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3629 / 3631

页数：3

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