Does the principle of minimum work apply at the carotid bifurcation: a retrospective cohort study

被引:14
作者
Beare, Richard J. [1 ,2 ]
Das, Gita [1 ]
Ren, Mandy [1 ]
Chong, Winston [3 ]
Sinnott, Matthew D. [4 ]
Hilton, James E. [4 ]
Srikanth, Velandai [1 ,5 ]
Phan, Thanh G. [1 ,6 ]
机构
[1] Monash Univ, Stroke & Aging Res Grp, Dept Med, Clayton, Vic 3800, Australia
[2] Royal Melbourne Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia
[3] Monash Med Ctr, Dept Radiol, Melbourne, Vic, Australia
[4] CSIRO Math Informat & Stat, Melbourne, Vic, Australia
[5] Univ Tasmania, Menzies Res Inst, Hobart, Tas, Australia
[6] Monash Med Ctr, Stroke Unit, Melbourne, Vic, Australia
关键词
SCALING LAWS; RISK-FACTOR; GEOMETRY; ANGLE; ARTERIES; ANATOMY; ORIGIN; FOLLOW; PLAQUE;
D O I
10.1186/1471-2342-11-17
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
100231 [临床病理学]; 100902 [航空航天医学];
摘要
Background: There is recent interest in the role of carotid bifurcation anatomy, geometry and hemodynamic factors in the pathogenesis of carotid artery atherosclerosis. Certain anatomical and geometric configurations at the carotid bifurcation have been linked to disturbed flow. It has been proposed that vascular dimensions are selected to minimize energy required to maintain blood flow, and that this occurs when an exponent of 3 relates the radii of parent and daughter arteries. We evaluate whether the dimensions of bifurcation of the extracranial carotid artery follow this principle of minimum work. Methods: This study involved subjects who had computed tomographic angiography (CTA) at our institution between 2006 and 2007. Radii of the common, internal and external carotid arteries were determined. The exponent was determined for individual bifurcations using numerical methods and for the sample using nonlinear regression. Results: Mean age for 45 participants was 56.9 +/- 16.5 years with 26 males. Prevalence of vascular risk factors was: hypertension-48%, smoking-23%, diabetes-16.7%, hyperlipidemia-51%, ischemic heart disease-18.7%. The value of the exponent ranged from 1.3 to 1.6, depending on estimation methodology. Conclusions: The principle of minimum work (defined by an exponent of 3) may not apply at the carotid bifurcation. Additional factors may play a role in the relationship between the radii of the parent and daughter vessels.
引用
收藏
页数:6
相关论文
共 25 条
[1]
[Anonymous], 2011, R: A Language and Environment for Statistical Computing
[2]
Beare R, 2010, INT C DIG IM COMP TE
[3]
A NEW CHARACTERIZATION OF 3-DIMENSIONAL SIMPLE POINTS [J].
BERTRAND, G ;
MALANDAIN, G .
PATTERN RECOGNITION LETTERS, 1994, 15 (02) :169-175
[4]
Configuration of intracranial arteries and development of aneurysms - A follow-up study [J].
Bor, A. Stijntje E. ;
Velthuis, Birgitta K. ;
Majoie, Charles B. ;
Rinkel, Gabriel J. E. .
NEUROLOGY, 2008, 70 (09) :700-705
[5]
Fisher M, 1990, STROKE, V21, P227
[6]
In vivo association between low wall shear stress and plaque in subjects with asymmetrical carotid atherosclerosis [J].
Gnasso, A ;
Irace, C ;
Carallo, C ;
DeFranceschi, MS ;
Motti, C ;
Mattioli, PL ;
Pujia, A .
STROKE, 1997, 28 (05) :993-998
[7]
Biophysical mechanisms of stroke [J].
Hademenos, GJ ;
Massoud, TF .
STROKE, 1997, 28 (10) :2067-2077
[8]
Comparison of vessel geometry in bifurcation between normal and diseased segments: Intravascular ultrasound analysis [J].
Hahn, Joo-Yong ;
Gwon, Hyeon-Cheol ;
Kwon, Sung Uk ;
Choi, Seung-Hyuk ;
Choi, Jin-Ho ;
Lee, Sang Hoon ;
Hong, Kyung-Pyo ;
Park, Jeong Euy ;
Kim, Duk Kyung .
ATHEROSCLEROSIS, 2008, 201 (02) :326-331
[9]
VESSEL CALIBER AND BRANCH-ANGLE OF HUMAN CORONARY-ARTERY BRANCH-POINTS [J].
HUTCHINS, GM ;
MINER, MM ;
BOITNOTT, JK .
CIRCULATION RESEARCH, 1976, 38 (06) :572-576
[10]
Bifurcation geometry and the presence of cerebral artery aneurysms [J].
Ingebrigtsen, T ;
Morgan, MK ;
Faulder, K ;
Ingebrigtsen, L ;
Sparr, T ;
Schirmer, H .
JOURNAL OF NEUROSURGERY, 2004, 101 (01) :108-113