An optimized predictive strategy for interactome mapping

被引：2

作者：

Aryee, Martin J. A. ^{[1
]}

Quackenbush, John ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2008年 / 7卷 / 09期

关键词：

protein-protein interaction; interactome; yeast two-hybrid;

D O I：

10.1021/pr700858e

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present an optimized experimental strategy that can accelerate progress toward identifying the majority of pairwise protein interactions. Our method involves applying a predictive algorithm, based on the existing data, to identify protein pairs likely to interact and prioritizing these for screening. The approach is iterative as additional data allows one to refine predictions directing the next stage of experimentation.

引用

页码：4089 / 4094

页数：6

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