Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

被引：181

作者：

Toshima, K ^{[1
]}

Takano, R ^{[1
]}

Ozawa, T ^{[1
]}

Matsumura, S ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 03期

关键词：

D O I：

10.1039/b107829c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5 side guanine of 5'-GG-3' site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline-carbohydrate) hybrid system was very effective for DNA cleavage.

引用

页码：212 / 213

页数：2

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