Phase behavioral effects on particle formation processes using supercritical fluids

被引：108

作者：

Palakodaty, S

York, P

机构：

[1] Bradford Particle Design Ltd, Bradford, W Yorkshire, England

[2] Univ Bradford, Sch Pharm, Drug Delivery Grp, Bradford BD7 1DP, W Yorkshire, England

来源：

PHARMACEUTICAL RESEARCH | 1999年 / 16卷 / 07期

关键词：

pharmaceuticals; materials processing; supercritical fluid processing; particles;

D O I：

10.1023/A:1011957512347

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The application of supercritical fluid (SF) processing in pharmaceutical research is increasing particularly in the field of particle formation for drug delivery systems. The SF processes have benefits over the existing particle formation methods in terms of improved control, flexibility and operational ease. This review highlights the fundamental concepts of fluid phase behaviour and their influence on the various processes involving particle formation with supercritical fluids. Several phase behaviour systems are discussed to provide an insight into the factors influencing the process paths and their effects on the characteristics of the particles.

引用

页码：976 / 985

页数：10

共 56 条

[1] Particle production of steroid drugs using supercritical fluid processing [J].