Neuroprotective effect of atypical antipsychotics in cognitive and non-cognitive behavioral impairment in animal models

被引：25

作者：

He, Jue ^{[1
,3
]}

Kong, Jiming ^{[2
]}

Tan, Qing-Rong ^{[3
]}

Li, Xin-Min ^{[1
,2
]}

机构：

[1] Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB R3E 3N4, Canada

[2] Univ Manitoba, Fac Med, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 3N4, Canada

[3] Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China

来源：

CELL ADHESION & MIGRATION | 2009年 / 3卷 / 01期

基金：

加拿大健康研究院;

关键词：

atypical antipsychotics; neuroprotective effect; memory; anxiety-like behavior; neurotoxicity;

D O I：

10.4161/cam.3.1.7401

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Antipsychotic drugs are divided into two groups: typical and atypical. Recent clinical studies show atypical antipsychotics have advantages over typical antipsychotics in a wide variety of neuropsychiatric conditions, in terms of greater efficacy for positive and negative symptoms, beneficial effects on cognitive functioning, and fewer extra pyramidal side effects in treating schizophrenia. As such, atypical antipsychotics may be effective in the treatment of depressive symptoms associated with psychotic and mood disorders, posttraumatic stress disorder and psychosis in Alzheimer disease. In this paper, we describe the effects and potential neurochemical mechanisms of action of atypical antipsychotics in several animal models showing memory impairments and/or non-cognitive behavioral changes. The data provide new insights into the mechanisms of action of atypical antipsychotics that may broaden their clinical applications.

引用

页码：129 / 137

页数：9

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