Distinct developmental expression of synaptotagmin I and IX in the mouse brain

被引：15

作者：

Fukuda, M ^{[1
]}

机构：

[1] RIKEN, Inst Phys & Chem Res, Fukuda Initiat Res Unit, Wako, Saitama 35101, Japan

来源：

NEUROREPORT | 2006年 / 17卷 / 02期

关键词：

subcellular fractions; synaptic vesicles; synaptotagmin IX;

D O I：

10.1097/01.wnr.0000198435.14142.be

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Synaptotagmin IX has been postulated to function as a major Ca2+ sensor for dense-core vesicle exocytosis in neuroendocrine cells. In this study, we investigated the subcellular localization and developmental expression profile of synaptotagmin IX in the mouse brain and found that it is mainly present in the dense-core vesicle fraction, which is devoid of synaptotagmin I and synaptophysin. We also found that the synaptotagmin IX expression level is constant throughout the postnatal development of the mouse brain, whereas the synaptotagmins I, II, III, VI, and XII are upregulated in parallel with synaptogenesis. These findings suggest that synaptotagmin IX regulates the transpon. of certain vesicles in the brain other than synaptic vesicles.

引用

页码：179 / 182

页数：4

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