Highly substituted enynes via a palladium-catalyzed tandem three carbon-carbon bonds forming reaction procedure from benzyl halides and alkynyl tributyltin reagents

被引：9

作者：

Pottier, LR ^{[1
]}

Peyrat, JF ^{[1
]}

Alami, M ^{[1
]}

Brion, JD ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Pharm, CNRS, Chim Therapeut Lab,UMR 8076, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 21期

关键词：

Stille coupling; benzyl halides; alkynylstannanes; palladium; enynes; four-component coupling;

D O I：

10.1016/j.tetlet.2004.03.173

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first report of the palladium-catalyzed cross coupling reaction of benzyl halides with alkynyl tributyltin reagents is described. This unprecedented coupling, which involves in a single reaction a tandem Stille-carbopalladation-Stille sequence allows the formation of three carbon-carbon bonds chemo-, regio- and stereoselectively and provides an efficient synthesis of highly substituted enynes. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4035 / 4038

页数：4

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