The flavonoid galangin inhibits the L1 metallo-β-lactamase from Stenotrophomonas maltophilia

被引：27

作者：

Denny, BJ ^{[1
]}

Lambert, PA

West, PWJ

机构：

[1] Kuwait Univ, Fac Pharm, Dept Pharmaceut Chem, Kuwait, Kuwait

[2] Aston Univ, Dept Pharmaceut & Biol Sci, Birmingham B4 7ET, W Midlands, England

[3] Kuwait Univ, Fac Allied Hlth Sci & Nursing, Dept Med Lab Sci, Kuwait, Kuwait

来源：

FEMS MICROBIOLOGY LETTERS | 2002年 / 208卷 / 01期

关键词：

flavonoid; galangin; metallo-beta-lactamase; molecular modelling; Stenotrophomonas maltophilia;

D O I：

10.1016/S0378-1097(01)00580-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

The flavonoid galangin inhibits the partially purified metallo-beta-lactamase from Stenotrophomonas maltophilia. The effect was not reversed by the addition of ZnCl2 Suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme. (C) 2002 Federation of European Microbiological Societies, Published by Elsevier Science B.V. All rights reserved.

引用

页码：21 / 24

页数：4

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