bofC encodes a putative forespore regulator of the Bacillus subtilis sigma(K) checkpoint

被引：18

作者：

Gomez, M ^{[1
]}

Cutting, SM ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT MICROBIOL,PHILADELPHIA,PA 19104

来源：

MICROBIOLOGY-UK | 1997年 / 143卷

关键词：

Bacillus subtilis; sporulation; checkpoint; gene regulation;

D O I：

10.1099/00221287-143-1-157

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A mutation, bofC1, that restores sigma(K) activation in Bacillus subtilis strains unable to produce active sigma(G) has been identified. This mutation defines a new sporulation gene, bofC, that has been cloned and sequenced and encodes a 19 kDa protein. bofC is transcribed in the forespore by RNA polymerase associated with the transcription factors sigma(F) (E sigma(F)) and sigma(G) (E sigma(G)). BofC acts negatively on SpoIVB and the results described suggest that BofC regulates SpoIVB activity and its intercompartmental signalling role in the sigma(K) checkpoint.

引用

页码：157 / 170

页数：14

共 36 条

[1] CLONING AND CHARACTERIZATION OF DNA DAMAGE-INDUCIBLE PROMOTER REGIONS FROM BACILLUS-SUBTILIS [J].