Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease

被引：129

作者：

Shen, Yun ^{[1
]}

Ma, Xiaojing ^{[1
]}

Zhou, Jian ^{[1
]}

Pan, Xiaoping ^{[1
]}

Hao, Yaping ^{[1
]}

Zhou, Mi ^{[1
]}

Lu, Zhigang ^{[2
]}

Gao, Meifang ^{[2
]}

Bao, Yuqian ^{[1
]}

Jia, Weiping ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol & Metab, Shanghai Key Lab Diabet Mellitus,Shanghai Diabet, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Cardiol, Shanghai 200030, Peoples R China

来源：

CARDIOVASCULAR DIABETOLOGY | 2013年 / 12卷

基金：

中国国家自然科学基金;

关键词：

Fibroblast growth factor 21; Coronary artery disease; Non-alcoholic fatty liver disease; Metabolic syndrome; NONALCOHOLIC FATTY LIVER; METABOLIC REGULATOR; INSULIN-RESISTANCE; FGF-21; OBESITY;

D O I：

10.1186/1475-2840-12-124

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background: Expression and activity of the fibroblast growth factor (FGF) 21 hormone-like protein are associated with development of several metabolic disorders. This study was designed to investigate whether serum FGF21 level was also associated with the metabolic syndrome-related cardiovascular disease, atherosclerosis, and its clinical features in a Chinese cohort. Methods: Two-hundred-and-fifty-three subjects visiting the Cardiology Department (Sixth People's Hospital affiliated to Shanghai JiaoTong University) were examined by coronary arteriography (to diagnose coronary artery disease (CAD)) and hepatic ultrasonography (to diagnose non-alcoholic fatty liver disease (NAFLD)). Serum FGF21 level was measured by enzyme-linked immunosorbent assay and analyzed for correlation to subject and clinical characteristics. The independent factors of CAD were determined by multivariate logistic regression analysis. Results: Subjects with NAFLD showed significantly higher serum FGF21 than those without NAFLD (388.0 pg/mL (253.0-655.4) vs. 273.3 pg/mL (164.9-383.7), P < 0.01). Subjects with CAD showed significantly higher serum FGF21, regardless of NAFLD diagnosis (P < 0.05). Serum FGF21 level significantly elevated with the increasing number of metabolic disorders (P for trend < 0.01). After adjustment of age, sex, and BMI, FGF21 was positively correlated with total cholesterol (P < 0.05) and triglyceride (P < 0.01). FGF21 was identified as an independent factor of CAD (odds ratio = 2.984, 95% confidence interval: 1.014-8.786, P < 0.05). Conclusions: Increased level of serum FGF21 is associated with NAFLD, metabolic disorders and CAD.

引用

页数：7

共 26 条

[1]

Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques [J].