Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain

被引：184

作者：

Zhou, C ^{[1
]}

Yu, GQ

Furuya, D

Greenberg, JH

Yodh, AG

Durduran, T

机构：

[1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA

[2] Univ Penn, Cerebrovasc Res Ctr, Dept Neurol, Philadelphia, PA 19104 USA

来源：

OPTICS EXPRESS | 2006年 / 14卷 / 03期

关键词：

D O I：

10.1364/OE.14.001125

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Diffuse optical correlation methods were adapted for three-dimensional (3D) tomography of cerebral blood flow (CBF) in small animal models. The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization. The tomographic approach was demonstrated with simulated data and during in-vivo cortical spreading depression (CSD) in rat brain. Three-dimensional images of CBF were obtained through intact skull in tissues deep (similar to 4 mm) below the skull surface. (c) 2006 Optical Society of America.

引用

页码：1125 / 1144

页数：20

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