Hepatic Steatosis and Peroxisomal Fatty Acid Beta-oxidation

被引：66

作者：

Cherkaoui-Malki, Mustapha ^{[1
]}

Surapureddi, Sailesh ^{[2
]}

El Hajj, Hammam I. ^{[1
]}

Vamecq, Joseph ^{[3
]}

Andreoletti, Pierre ^{[1
]}

机构：

[1] Univ Bourgogne, EA 7270, BioperoxIL, Lab Biochim Peroxysome Inflammat & Metab Lipid, F-21000 Dijon, France

[2] NIEHS, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA

[3] CHRU Lille, Dept Biochem & Mol Biol, Lab Hormonol Metab Nutr & Oncol, Ctr Biol & Pathol Pierre Marie Degand, F-59037 Lille, France

来源：

CURRENT DRUG METABOLISM | 2012年 / 13卷 / 10期

关键词：

ACOX1; Coactivators; hepatic Steatosis; hepatocarcinogenesis; MED1; NASH; beta-oxidation; Peroxisome; Peroxisomes proliferation; PPARalpha; PROLIFERATOR-ACTIVATED-RECEPTOR; ACYL-COA OXIDASE; RAT-LIVER PEROXISOMES; TUMOR-NECROSIS-FACTOR; PALMITOYLTRANSFERASE I GENE; CARRIER PROTEIN-X; THIOLASE-B GENE; PPAR-ALPHA; BINDING-PROTEIN; ENOYL-COA;

D O I：

10.2174/138920012803762765

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Three subhepatocellular compartments concur for fatty acids degradation including omega-oxidation in endoplasmic reticulum and beta-oxidation in both mitochondria and peroxisomes. Deficits affecting the peroxisomal physiology may be associated with multiple metabolic disturbances. Nowadays, a growing body of evidence underlines the key role of peroxisomal beta-oxidation in the sensing of lipid metabolism through the production/degradation of some essential metabolites. Lessons from several mice models strengthen the link between fatty acid beta-oxidation in peroxisomes and the nuclear hormone receptor Peroxisome Proliferator-Activated Receptor (PPAR)-alpha with an additional level of coregualtor complexity, which couples regulation of body energetic balance and hepatic caloric flux to functional peroxisome status. Here, we review key determinants of disrupted peroxisomal beta-oxidation pathway, which in liver promotes hepatic steatosis and hepatocarcinogenesis.

引用

页码：1412 / 1421

页数：10

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