Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: Dose-finding study with no concomitant use of hypnotic agent

被引：29

作者：

Mashiko, H

Niwa, S

Kumashiro, H

Kaneko, Y

Suzuki, S

Numata, Y

Horikoshi, R

Watanabe, Y

机构：

[1] Fukushima Med Univ, Dept Neuropsychiat, Sch Med, Fukushima 9601295, Japan

[2] Shirakawa Kosei Gen Hosp, Shirakawa, Japan

[3] Maikohama Hosp, Iwaki, Fukushima, Japan

[4] Prefectural Aizu Gen Hosp, Aizuwakamatsu, Japan

[5] Fukushima Red Cross Hosp, Fukushima, Japan

[6] Horikoshi Psychosomat Clin, Fukushima, Japan

[7] Nanko Hosp, Shirakawa, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 1999年 / 53卷 / 02期

关键词：

benzodiazepines; depression; single dose; sleep; trazodone;

D O I：

10.1046/j.1440-1819.1999.00532.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.

引用

页码：193 / 194

页数：2