Current strategies in systemic treatment of gastric cancer and cancer of the gastroesophageal junction

被引：68

作者：

Menges, Markus ^{[1
]}

Hoehler, Thomas ^{[2
]}

机构：

[1] Diakonie Klinikum gGmbH, Dept Internal Med, D-74523 Schwaebisch Hall, Germany

[2] Prosper Hosp, Dept Med 1, Recklinghausen, Germany

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2009年 / 135卷 / 01期

关键词：

Gastric cancer; Gastroesophageal junction cancer; Systemic therapy; Neoadjuvant chemotherapy; Adjuvant radiochemotherapy; Palliative chemotherapy; New chemotherapeutic agents; PHASE-II TRIAL; ADVANCED ESOPHAGOGASTRIC CANCER; ARBEITSGEMEINSCHAFT-INTERNISTISCHE-ONKOLOGIE; RANDOMIZED CONTROLLED-TRIAL; LONG-TERM SURVIVAL; S-1 PLUS CISPLATIN; ADJUVANT CHEMOTHERAPY; CURATIVE RESECTION; CONTINUOUS-INFUSION; 1ST-LINE THERAPY;

D O I：

10.1007/s00432-008-0425-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer is a major health issue and a leading cause of death worldwide. The results of standard therapy remain unsatisfactory mainly because of diagnosis at the late stage of disease. Innovative strategies such as neoadjuvant chemotherapy in locally advanced cancer have improved the outcome even in operable cases. Whether an adjuvant radiochemotherapy is of benefit after curative resection including systematic lymphadenectomy remains yet unclear. Some progress has been made in the palliative setting by introducing new substances. This review examines recent advances in the systemic treatment of gastric and gastroesophageal junction cancer.

引用

页码：29 / 38

页数：10

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