The mammalian secreted RNases: Mechanisms of action in host defence

被引：73

作者：

Gupta, Sandeep K. ^{[2
]}

Haigh, Brendan J.

Griffin, Frank J. ^{[2
]}

Wheeler, Thomas T. ^{[1
]}

机构：

[1] AgResearch, Dairy Foods Food & Biobased Prod, Ruakura Res Ctr, Hamilton, New Zealand

[2] Univ Otago, Dept Microbiol & Immunol, Dunedin, New Zealand

来源：

INNATE IMMUNITY | 2013年 / 19卷 / 01期

关键词：

RNase; angiogenin; antimicrobial; cytotoxins; mucosal immunity; EOSINOPHIL CATIONIC PROTEIN; RIBONUCLEASE-A SUPERFAMILY; BOVINE SEMINAL RIBONUCLEASE; MEMBRANE INTERACTION MECHANISM; SCHISTOSOMA-MANSONI INFECTION; MAJOR BASIC-PROTEIN; ANTIMICROBIAL PEPTIDE; IMMUNOSUPPRESSIVE ACTIVITY; DIFFERENTIAL EXPRESSION; COMPARATIVE TOXICITY;

D O I：

10.1177/1753425912446955

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The mammalian ribonucleaseA family comprises a large group of structurally similar proteins which are secreted by a range of tissues and immune cells. Their physiological role is unclear. It has been suggested that some of these RNases contribute to host defence, notably eosinophil-derived neurotoxin, eosinophil cationic protein, eosinophil-associated RNases, RNase4, angiogenin (RNase5), RNase7, RNase8 and bovine seminal RNase. This review summarises data supporting the involvement of these proteins in host defence, focusing on their antimicrobial, cytotoxic and immunomodulatory activities. The extent to which the data support possible mechanisms of action for these proteins is discussed. This compilation of findings and current hypotheses on the physiological role of these RNases will provide a stimulus for further research and development of ideas on the contribution of the RNases to host defence.

引用

页码：86 / 97

页数：12

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