Molecular and functional aspects of latent transforming growth factor-β binding protein:: just a masking protein?

被引：39

作者：

Mangasser-Stephan, K ^{[1
]}

Gressner, AM ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Univ Klinikum, Zent Lab, Inst Klin Chem & Pathobiochem, D-52057 Aachen, Germany

来源：

CELL AND TISSUE RESEARCH | 1999年 / 297卷 / 03期

关键词：

LTBP; isoforms; splice variants; extracellular matrix; TGF beta;

D O I：

10.1007/s004410051364

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Latent transforming growth factor-beta (TGF beta) binding protein (LTBP), a component of the high-molecular-weight latent TGF beta complex, is found in various cell and tissue types. Originally described as a TGF beta-masking protein, recent detections of four isoforms and numerous splice variants provide new aspects of its putative functional role. Regulation and sequestration of TGF beta activity and structural remodeling of the extracellular matrix (ECM) seem to be the main tasks, but other possible functions might exist. The mechanism by which LTBP interacts with cell surface molecules or cellular receptors and ECM components remains unclear. Cellular, molecular and functional aspects will be discussed.

引用

页码：363 / 370

页数：8

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