Frailty and cognitive impairment-A review of the evidence and causal mechanisms

被引:684
作者
Robertson, Deirdre A. [1 ]
Savva, George M. [1 ,2 ]
Kenny, Rose Anne [1 ]
机构
[1] Trinity Coll Dublin, Dept Med Gerontol, Dublin, Ireland
[2] Univ E Anglia, Sch Nursing Sci, Norwich NR4 7TJ, Norfolk, England
关键词
Frailty; Cognition; Dementia; Cognitive impairment; ADVERSE HEALTH OUTCOMES; ALZHEIMERS-DISEASE; PHYSICAL FRAILTY; SOCIAL VULNERABILITY; OLDER OUTPATIENTS; VASCULAR DEMENTIA; ELDERLY-PEOPLE; GAIT SPEED; DECLINE; RISK;
D O I
10.1016/j.arr.2013.06.004
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Incidence rates of cognitive impairment and dementia are rising with the ageing population. Meanwhile, the limited success of current treatments has led to a search for early markers of dementia which could predict future progression or improve quality of life for those already suffering from the disease. One focus has been on the correlation between physical and cognitive measures with an increasing interest in the association between frailty and cognitive decline. Frailty is an age-related syndrome described as the decreased ability of an organism to respond to stressors. A number of epidemiological studies have reported that frailty increases the risk of future cognitive decline and that cognitive impairment increases the risk of frailty suggesting that cognition and frailty interact within a cycle of decline associated with ageing. This paper reviews the evidence for an association between frailty and cognitive impairment and outlines some of the mechanisms that potentially underpin this relationship from brain neuropathology and hormonal dysregulation to cardiovascular risk and psychological factors. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:840 / 851
页数:12
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