Polyethylene glycol-phosphatidylethanolamine (PEG-PE)/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer

被引：132

作者：

Abouzeid, Abraham H. ^{[1
]}

Patel, Niravkumar R. ^{[1
]}

Torchilin, Vladimir P. ^{[1
]}

机构：

[1] Northeastern Univ, Dept Pharmaceut Sci, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2014年 / 464卷 / 1-2期

关键词：

Curcumin; Nuclear factor-kappa B (NF-kappa B); Mixed micelles; Multi-drug resistance; Combination therapy; Ovarian cancer; IN-VITRO; DRUG-DELIVERY; FORMULATION; VIVO; CHEMOTHERAPY; COMBINATION; ABSORPTION; EFFICACY; CELLS;

D O I：

10.1016/j.ijpharm.2014.01.009

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The therapeutic potential of mixed micelles, made of PEG-PE and vitamin E co-loaded with curcumin and paclitaxel, was investigated against SK-OV-3 human ovarian adenocarcinoma along with its multi-drug resistant version SK-OV-3-paclitaxel-resistant (TR) cells in vitro and in vivo. The addition of curcumin at various concentrations did not significantly enhance the cytotoxicity of paclitaxel against SK-OV-3 in vitro. However, a clear synergistic effect was observed with the combination treatment against SK-OV-3TR in vitro. In vivo, this combination treatment produced a three-fold tumor inhibition with each of these cell lines. Our results indicate that such co-loaded mixed micelles could have significant clinical advantages for the treatment of resistant ovarian cancer. (C) 2014 Elsevier B.V. All rights reserved.

引用

收藏

页码：178 / 184

页数：7

相关论文

共 21 条

[1]

Curcumin and cancer: An "old-age" disease with an "age-old" solution [J].

Anand, Preetha ;

Sundaram, Chitra ;

Jhurani, Sonia ;

Kunnumakkara, Ajaikumar B. ;

Aggarwal, Bharat B. .

CANCER LETTERS, 2008, 267 (01) :133-164

[2]

RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo (Retracted article. See vol. 102, pg. 143, 2016) [J].

Anand, Preetha ;

Nair, Hareesh B. ;

Sung, Bokyung ;

Kunnumakkara, Ajaikumar B. ;

Yadav, Vivek R. ;

Tekmal, Rajeshwar R. ;

Aggarwal, Bharat B. .

BIOCHEMICAL PHARMACOLOGY, 2010, 79 (03) :330-338

[3]

Akt is upstream and MAPKs are downstream of NF-κB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism [J].

Bava, Smitha V. ;

Sreekanth, Chanickal N. ;

Thulasidasan, Arun Kumar T. ;

Anto, Nikhil P. ;

Cheriyan, Vino T. ;

Puliyappadamba, Vineshkumar T. ;

Menon, Sajna G. ;

Ravichandran, Santhosh D. ;

Anto, Ruby John .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2011, 43 (03) :331-341

[4]

QUANTITATIVE-ANALYSIS OF DOSE-EFFECT RELATIONSHIPS - THE COMBINED EFFECTS OF MULTIPLE-DRUGS OR ENZYME-INHIBITORS [J].

CHOU, TC ;

TALALAY, P .

ADVANCES IN ENZYME REGULATION, 1984, 22 :27-55

[5]

Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems [J].

Cui, Jing ;

Yu, Bo ;

Zhao, Yu ;

Zhu, Weiwei ;

Li, Houli ;

Lou, Hongxiang ;

Zhai, Guangxi .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 371 (1-2) :148-155

[6]

Coadministration of Paclitaxel and Curcumin in Nanoemulsion Formulations To Overcome Multidrug Resistance in Tumor Cells [J].

Ganta, Srinivas ;

Amiji, Mansoor .

MOLECULAR PHARMACEUTICS, 2009, 6 (03) :928-939

[7]

Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation [J].

Gelderblom, H ;

Verweij, J ;

Nooter, K ;

Sparreboom, A .

EUROPEAN JOURNAL OF CANCER, 2001, 37 (13) :1590-1598

[8]

Mixed micelles of PEG2000-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: Enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines [J].

Gill, Kanwaldeep K. ;

Kaddoumi, Amal ;

Nazzal, Sami .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 46 (1-2) :64-71

[9]

Curcumin as "Curecumin":: From kitchen to clinic [J].

Goel, Ajay ;

Kunnumakkara, Ajaikumar B. ;

Aggarwal, Bharat B. .

BIOCHEMICAL PHARMACOLOGY, 2008, 75 (04) :787-809

[10]

Transport of liposomal and albumin loaded curcumin to living cells: An absorption and fluorescence spectroscopic study [J].

Kunwar, Amit ;

Barik, Atanu ;

Pandey, Ruchi ;

Priyadarsini, K. Indira .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 1760 (10) :1513-1520