Synthesis and characterization of a novel alginate-poly (ethylene glycol) graft copolymer

被引：119

作者：

Laurienzo, P

Malinconico, M

Motta, A

Vicinanza, A

机构：

[1] CNR, Ist Chim & Technol Polimeri, I-80078 Pozzueli, Naples, Italy

[2] CNR, Ist Chim Biomol, I-80078 Pozzueli, Naples, Italy

来源：

CARBOHYDRATE POLYMERS | 2005年 / 62卷 / 03期

关键词：

alginate; polyethyleneglycol; carbodiimide chemistry; NMR spectroscopy;

D O I：

10.1016/j.carbpol.2005.08.005

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

Sodium alginate grafted with low molecular weight polyethylene glycol (PEG) was prepared by reacting a mono-carboxyl terminated PEG with a sodium alginate modified by inserting a given amount of amine functionalities. The coupling between PEG and alginate was carried out using carbodiimide chemistry in aqueous solutions. Significant reduction of the molecular weight of alginate is recorded, as expected from literature reports. The chosen strategy allowed to graft significant amounts of PEG saving the carboxylic functionalities of alginate, necessary for the cross-linking of the polysaccharide. The chemical structure and chemical-physical properties of alginate derivatives were characterized by FTIR, H-1 and C-13 NMR, DSC, TGA and wide angle X-ray analysis. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：274 / 282

页数：9

共 21 条

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CONCERNING EFFECT OF PERIODATE OXIDATION UPON INTRINSIC-VISCOSITY OF ALGINATE [J].