Neural correlates of conceptual object priming in young and older adults: an event-related functional magnetic resonance imaging study

被引:29
作者
Ballesteros, Soledad [1 ]
Bischof, Gerard N. [2 ,3 ]
Goh, Joshua O. [3 ,4 ]
Park, Denise C. [2 ,3 ]
机构
[1] Univ Nacl Educ Distancia, Dept Basic Psychol 2, E-28040 Madrid, Spain
[2] Univ Texas Dallas, Ctr Vital Longev, Dallas, TX 75230 USA
[3] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA
[4] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA
关键词
Aging; fMRI; Repetition priming; Priming; Implicit memory; Recognition; AGE-RELATED-CHANGES; BRAIN ACTIVITY; ALZHEIMERS-DISEASE; AGING AFFECTS; LIFE-SPAN; IMPLICIT MEMORY; REPETITION; RECOGNITION; COMPONENTS; POTENTIALS;
D O I
10.1016/j.neurobiolaging.2012.09.019
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
In this event-related functional magnetic resonance imaging study, we investigated age-related differences in brain activity associated with conceptual repetition priming in young and older adults. Participants performed a speeded "living/nonliving" classification task with 3 repetitions of familiar objects. Both young and older adults showed a similar magnitude of behavioral priming to repeated objects and evidenced repetition-related activation reductions in fusiform gyrus, superior occipital, middle, and inferior temporal cortex, and inferior frontal and insula regions. The neural priming effect in young adults was extensive and continued through both the second and third stimulus repetitions, and neural priming in older adults was markedly attenuated and reached floor at the second repetition. In young adults, greater neural priming in multiple brain regions correlated with greater behavioral facilitation and in older adults, only activation reduction in the left inferior frontal correlated with faster behavioral responses. These findings provide evidence for altered neural priming in older adults despite preserved behavioral priming, and suggest the possibility that age-invariant behavioral priming is observed as a result of more sustained neural processing of stimuli in older adults which might be a form of compensatory neural activity. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:1254 / 1264
页数:11
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