Regulation of glucose metabolism-related genes and VEGF by HIF-1α and HIF-1β, but not HIF-2α, in gastric cancer

被引：37

作者：

Song, In-Sung ^{[1
]}

Wang, Ai-Guo ^{[1
]}

Yoon, Sun Young ^{[1
]}

Kim, Jeong-Min ^{[1
]}

Kim, Joo Heon ^{[2
]}

Lee, Dong-Seok ^{[3
]}

Kim, Nam-Soon ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Genome Res Ctr, Taejon 305806, South Korea

[2] Eulji Univ, Sch Med, Dept Pathol, Taejon 301746, South Korea

[3] Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Taegu 702701, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2009年 / 41卷 / 01期

关键词：

glucose metabolism disorders; hypoxia-inducible factor 1; neovascularization; pathologic; stomach neoplasms; vascular endothelial growth factor A; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; EXPRESSED SEQUENCE TAGS; UNFAVORABLE PROGNOSIS; CELLS; OVEREXPRESSION; IDENTIFICATION; GROWTH; LUNG;

D O I：

10.3858/emm.2009.41.1.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of target genes involved in crucial aspects of cancer development. This study investigated the expression of HIFs and their contribution to the regulation of target genes related to angiogenesis and glucose metabolism in gastric cancer. The data showed that HIFs were over-expressed in gastric cancer and that activation of the target genes was observed mainly in the early stages. Moreover, the results of the present study revealed that only HIF-1 alpha, but not HIF-2 alpha dimerizes with HIF-1 beta and then regulates expression of target genes in response to hypoxia. The results of the present study demonstrate that HIF-1 alpha and HIF-1 beta enhances expression of VEGF and glucose metabolism-related genes in response to hypoxia in gastric cancer. These data offer important information regarding HIF pathways in the development of gastric cancer.

引用

页码：51 / 58

页数：8

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