Sample size calculations for pilot randomized trials: a confidence interval approach

被引：318

作者：

Cocks, Kim ^{[1
]}

Torgerson, David J. ^{[1
]}

机构：

[1] Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England

来源：

JOURNAL OF CLINICAL EPIDEMIOLOGY | 2013年 / 66卷 / 02期

关键词：

Sample size; Pilot trials; Confidence intervals; Statistical power; Review; Randomised trials; EFFICIENCY; POWER;

D O I：

10.1016/j.jclinepi.2012.09.002

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

100404 [儿少卫生与妇幼保健学];

摘要：

Objectives: To describe a method using confidence intervals (CIs) to estimate the sample size for a pilot randomized trial. Study Design: Using one-sided CIs and the estimated effect size that would be sought in a large trial, we calculated the sample size needed for pilot trials. Results: Using an 80% one-sided CI, we estimated that a pilot trial should have at least 9% of the sample size of the main planned trial. Conclusion: Using the estimated effect size difference for the main trial and using a one-sided CI, this allows us to calculate a sample size for a pilot trial, which will make its results more useful than at present. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：197 / 201

页数：5

共 14 条

[1]

What is a pilot or feasibility study? A review of current practice and editorial policy [J].