Cellular contributions to glomerular size-selectivity

被引：16

作者：

Deen, WM ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

KIDNEY INTERNATIONAL | 2006年 / 69卷 / 08期

关键词：

D O I：

10.1038/sj.ki.5000322

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The glomerular capillary wall permits free passage of low-molecular-weight solutes, while severely restricting large proteins. Although both cell layers ( endothelium and epithelium) almost certainly contribute to this size-selectivity, their relative importance has been difficult to assess. The finding by Rippe et al. of an inverse relationship between the sieving coefficient of Ficoll and glomerular filtration rate sheds light on this.

引用

页码：1295 / 1297

页数：3

共 8 条

[1] PERMSELECTIVITY OF GLOMERULAR CAPILLARY WALL TO MACROMOLECULES .2. EXPERIMENTAL STUDIES IN RATS USING NEUTRAL DEXTRAN [J].