Indications, Labeling, and Outcomes Assessment for Drugs Aimed at Improving Functional Status in Older Persons: A Conversation Between Aging Researchers and FDA Regulators

被引：19

作者：

Bhasin, Shalender ^{[1
]}

Espeland, Mark A. ^{[2
]}

Evans, William J. ^{[3
]}

Ferrucci, Luigi ^{[4
]}

Fried, Linda P. ^{[5
]}

Gill, Thomas M. ^{[6
]}

Pahor, Marco ^{[7
]}

Studenski, Stephanie ^{[8
]}

Guralnik, Jack ^{[9
]}

Nayfi, Susan ^{[10
]}

Romashkin, Sergei ^{[10
]}

Perlstein, Robert ^{[11
]}

Burke, Laurie ^{[11
]}

Parks, Mary ^{[11
]}

机构：

[1] Boston Univ, Sch Med, Boston, MA 02215 USA

[2] Wake Forest Univ Hlth Sci, Dept Biostat Sci, Winston Salem, NC USA

[3] Univ Arkansas Med Sci, Donald W Reynolds Inst Aging, Little Rock, AR 72205 USA

[4] NIA, Baltimore Longitudinal Study Aging, Bethesda, MD 20892 USA

[5] Cornell Univ, Ithaca, NY 14853 USA

[6] Yale Univ, Sch Med, New Haven, CT 06520 USA

[7] Univ Florida, Sch Med, Gainesville, FL 32611 USA

[8] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA

[9] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[10] NIA, Geriatr & Clin Gerontol Program, Bethesda, MD 20892 USA

[11] US FDA, Rockville, MD 20857 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2009年 / 64卷 / 04期

关键词：

MUSCLE MASS SARCOPENIA; SKELETAL-MUSCLE; POSTMENOPAUSAL WOMEN; BODY-COMPOSITION; FRAILTY; STRENGTH; MEN; DISABILITY; CARE; OSTEOPOROSIS;

D O I：

10.1093/gerona/gln042

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

[No abstract available]

引用

页码：487 / 491

页数：5

共 31 条

[1] Low nutrient intake is an essential component of frailty in older persons [J].

Bartali, Benedetta ;

Frongillo, Edward A. ;

Bandinelli, Stefania ;

Lauretani, Fulvio ;

Semba, Richard D. ;

Fried, Linda P. ;

Ferrucci, Luigi .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2006, 61 (06) :589-593

[2] Epidemiology of sarcopenia among the elderly in New Mexico [J].

Baumgartner, RN ;

Koehler, KM ;

Gallagher, D ;

Romero, L ;

Heymsfield, SB ;

Ross, RR ;

Garry, PJ ;

Lindeman, RD .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1998, 147 (08) :755-763

[3] Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle [J].

Bhasin, S ;

Woodhouse, L ;

Casaburi, R ;

Singh, AB ;

Mac, RP ;

Lee, M ;

Yarasheski, KE ;

Sinha-Hikim, I ;

Dzekov, C ;

Dzekov, J ;

Magliano, L ;

Storer, TW .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (02) :678-688

[4] The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle [J].

Campbell, WW ;

Trappe, TA ;

Wolfe, RR ;

Evans, WJ .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2001, 56 (06) :M373-M380

[5] Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study [J].

Cesari, M ;

Leeuwenburgh, C ;

Lauretani, F ;

Onder, G ;

Bandinelli, S ;

Maraldi, C ;

Guralnik, JM ;

Pahor, M ;

Ferrucci, L .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 83 (05) :1142-1148

[6]

Evans WJ, 2008, J GERONTOL A-BIOL, V63, P160

[7] Editorial: Megestrol acetate use for weight gain should be carefully considered [J].

Evans, William J. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (02) :420-421

[8] WHAT IS SARCOPENIA [J].

EVANS, WJ .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1995, 50 :5-8

[9]

Ferrucci L, 2002, AGING CLIN EXP RES, V14, P1

[10] EXERCISE TRAINING AND NUTRITIONAL SUPPLEMENTATION FOR PHYSICAL FRAILTY LN VERY ELDERLY PEOPLE [J].

FIATARONE, MA ;

ONEILL, EF ;

RYAN, ND ;

CLEMENTS, KM ;

SOLARES, GR ;

NELSON, ME ;

ROBERTS, SB ;

KEHAYIAS, JJ ;

LIPSITZ, LA ;

EVANS, WJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (25) :1769-1775

← 1 2 3 4 →