Poly(2-ethyl-2-oxazoline) as Alternative for the Stealth Polymer Poly(ethylene glycol): Comparison of in vitro Cytotoxicity and Hemocompatibility

被引：299

作者：

Bauer, Marius ^{[1
]}

Lautenschlaeger, Christian ^{[1
]}

Kempe, Kristian ^{[2
]}

Tauhardt, Lutz ^{[2
]}

Schubert, Ulrich S. ^{[2
,3
]}

Fischer, Dagmar ^{[1
,3
]}

机构：

[1] Univ Jena, Dept Pharmaceut Technol, Inst Pharm, D-07745 Jena, Germany

[2] Univ Jena, Lab Organ & Macromol Chem IOMC, D-07743 Jena, Germany

[3] Univ Jena, Jena Ctr Soft Matter JCSM, D-07743 Jena, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 07期

关键词：

biocompatibility; hydrophilic polymers; poly(2-oxazoline)s; poly(ethylene glycol)s; stealth effect; LIVING POLYMERIZATION; POLYETHYLENE-GLYCOL; COLORIMETRIC ASSAY; BLOOD; MACROMOLECULES; VIABILITY; PROTEINS; ALCOHOL; CELLS;

D O I：

10.1002/mabi.201200017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Limitations of PEG in drug delivery have been reported from clinical trials. PEtOx (0.440?kDa) as alternative is synthesized by a living, microwave-assisted polymerization, and is directly compared to PEG of similar molar mass regarding cytotoxicity and hemocompatibility. In short-term treatments, both types of polymers are well tolerated even at high concentrations. Moderate concentration and molar mass dependent cytotoxic effects occurred only after long-term incubation at concentrations higher than therapeutic doses. PEtOx possesses not only an easy route of synthesis and beneficial physicochemical characteristics such as low viscosity and high stability, which are advantageous over PEG, but additionally in vitro toxicology comparable to PEG.

引用

页码：986 / 998

页数：13

共 42 条

[1]

[Anonymous], 2007, ASTM standard D698-07

[2]

[Anonymous], 2009, 109935 ANSI ISO

[3]

[Anonymous], 2008, ANN BOOK ASTM STAND

[4]

The hydrodynamic radii of macromolecules and their effect on red blood cell aggregation [J].