Molecular Imaging of Aortic Aneurysms

被引:8
作者
Buxton, Denis B. [1 ]
机构
[1] NHLBI, Div Cardiovasc Sci, Bethesda, MD 20817 USA
关键词
aneurysm; aorta; imaging; MATRIX-METALLOPROTEINASE ACTIVITY; INTRALUMINAL THROMBUS; INFLAMMATION; WALL; MANAGEMENT; AGENT; AAA;
D O I
10.1161/CIRCIMAGING.112.973727
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Animal studies have demonstrated that a wide range of tracers aimed at different pathophysiological elements can be used to detect AAs. These molecular imaging probes have the potential to provide complementary functional information that goes beyond the anatomic information obtained through diagnostic echocardiography or CT studies. Although anatomic imaging cannot predict future expansion of aneurysms, the functional information provided by molecular imaging agents may be able to predict future events. For some agents, for example CNA-35 targeting of collagen and 18F-labeled NP targeted to macrophages,23 proof-of-principle studies have confirmed that molecular imaging can provide information on AA functional status. For the collagen-targeted tracer, stable Stage II AAAs have a higher signal than ruptured Stage IV AAAs, reflecting the less-compromised status of the extracellular matrix.17 For 18F -NP, low uptake was associated with low growth, whereas AAs that took up high levels of tracer expanded rapidly.23 More extensive studies, including experiments in additional models of AA, will be needed to confirm the potential prognostic value of these and other molecular imaging strategies. © 2012 American Heart Association, Inc.
引用
收藏
页码:392 / 399
页数:8
相关论文
共 46 条
[1]   Altered patterns of gene expression distinguishing ascending aortic aneurysms from abdominal aortic aneurysms: Complementary DNA expression profiling in the molecular characterization of aortic disease [J].
Absi, TS ;
Sundt, TM ;
Tung, WS ;
Moon, M ;
Lee, JK ;
Damiano, RR ;
Thompson, RW .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2003, 126 (02) :344-357
[2]   The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial [J].
Ashton, HA ;
Buxton, MJ ;
Day, NE ;
Kim, LG ;
Marteau, TM ;
Scott, RAP ;
Thomspon, SG ;
Walker, NM .
LANCET, 2002, 360 (9345) :1531-1539
[3]   DISTAL EMBOLIZATION AS A PRESENTING SYMPTOM OF AORTIC-ANEURYSMS [J].
BAXTER, BT ;
MCGEE, GS ;
FLINN, WR ;
MCCARTHY, WJ ;
PEARCE, WH ;
YAO, JST .
AMERICAN JOURNAL OF SURGERY, 1990, 160 (02) :197-201
[4]   In Vivo Evaluation of a New Magnetic Resonance Imaging Contrast Agent (P947) to Target Matrix Metalloproteinases in Expanding Experimental Abdominal Aortic Aneurysms [J].
Bazeli, Romain ;
Coutard, Michele ;
Duport, Benjamin Daumas ;
Lancelot, Eric ;
Corot, Claire ;
Laissy, Jean-Pierre ;
Letourneur, Didier ;
Michel, Jean-Baptiste ;
Serfaty, Jean-Michel .
INVESTIGATIVE RADIOLOGY, 2010, 45 (10) :662-668
[5]   Report of the National Heart, Lung, and Blood Institute Working Group on the Translation of Cardiovascular Molecular Imaging [J].
Buxton, Denis B. ;
Antman, Melissa ;
Danthi, Narasimhan ;
Dilsizian, Vasken ;
Fayad, Zahi A. ;
Garcia, Mario J. ;
Jaff, Michael R. ;
Klimas, Michael ;
Libby, Peter ;
Nahrendorf, Matthias ;
Sinusas, Albert J. ;
Wickline, Samuel A. ;
Wu, Joseph C. ;
Bonow, Robert O. ;
Weissleder, Ralph .
CIRCULATION, 2011, 123 (19) :2157-2163
[6]   What is the role of screening in the management of abdominal aortic aneurysms? [J].
Dabare, Dilan ;
Lo, Tammy T. H. ;
McCormack, David J. ;
Kung, Victor W. S. .
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 2012, 14 (04) :399-405
[7]   Rationale and design of the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) [J].
Eagle, Kim A. .
AMERICAN HEART JOURNAL, 2009, 157 (02) :319-326
[8]   Pathogenesis of thoracic and abdominal aortic aneurysms [J].
Guo, Dong-Chuan ;
Papke, Christina L. ;
He, Rumin ;
Milewicz, Dianna M. .
ABDOMINAL AORTIC ANEURYSM: GENETICS, PATHOPHYSIOLOGY AND MOLECULAR BIOLOGY, 2006, 1085 :339-352
[9]   Size and location of thrombus in intact and ruptured abdominal aortic aneurysms [J].
Hans, SS ;
Jareunpoon, O ;
Balasubramaniam, M ;
Zelenock, GB .
JOURNAL OF VASCULAR SURGERY, 2005, 41 (04) :584-588
[10]  
HARTER LP, 1982, J ULTRAS MED, V1, P315