Association of the GPIa C807T and GPIIIa PIA1/A2 polymorphisms with premature myocardial infarction in men

Aims Recent studies have reported an association between the platelet glycoprotein (GP) Ia C807T polymorphism and myocardial infarction, whereas other Studies have reported contradictory results concerning the platelet GPIIIa P1(A1/A2) polymorphism. In most of these studies the patients were older than 45 years. Thus we decided to examine both genotypes in 287 men who had their first myocardial infarction before age 45, and a group of 138 healthy controls. Methods and Results The frequency of T-807 allele carriers was similar among myocardial infarction patients and among controls (54.6% vs 62.3%: odds ratio (OR) 0.73; 95% , confidence interval (CI), 0.47-1.12). The frequency of P1(A2) carriers was higher in cases than in controls (26.5%, vs 15.2%; OR 1.65, CI, 1.09-2.54). After performing a logistic regression analysis, taking into account other cardio-vascular risk factors, this difference did not remain significant. The combination of the risk alleles of both genotypes had no major effect on the myocardial infarction risk. Conclusions The GPIIIa P1(A2) allele is not independently associated with the risk of premature myocardial infarction. The T-807 allele of the GPIa gene alone or in combination with the P1(A2) allele had no major effect on premature myocardial infarction risk. (C) 2001 The European Society of Cardiology.