TCL1A expression delineates biological and clinical variability in B-cell lymphoma

被引：43

作者：

Aggarwal, Mohit ^{[1
]}

Villuendas, Raquel ^{[1
]}

Gomez, Gonzalo ^{[2
]}

Rodriguez-Pinilla, Socorro M. ^{[1
]}

Sanchez-Beato, Margarita ^{[1
]}

Alvarez, David ^{[1
]}

Martinez, Nerea ^{[1
]}

Rodriguez, Antonia ^{[1
]}

Castillo, Maria E. ^{[1
]}

Camacho, Francisca I. ^{[1
]}

Montes-Moreno, Santiago ^{[1
]}

Garcia-Marco, Jose A. ^{[3
]}

Kimby, Eva ^{[4
]}

Pisano, David G. ^{[2
]}

Piris, Miguel A. ^{[1
]}

机构：

[1] Spanish Natl Canc Res Ctr CNIO, Mol Pathol Programme, Madrid, Spain

[2] CNIO, Struct Biol & Biocomp Programme, Bioinformat Unit, Madrid, Spain

[3] Hosp Univ Puerta Hierro, Dept Haematol, Madrid, Spain

[4] Karolinska Inst, Dept Internal Med Huddinge, Div Hematol, Stockholm, Sweden

来源：

MODERN PATHOLOGY | 2009年 / 22卷 / 02期

关键词：

TCL1; B-cell lymphoma; gene expression; clinical variability; CHRONIC LYMPHOCYTIC-LEUKEMIA; TRANSGENIC MICE; REGULATORY NETWORKS; SIGNATURE; MOUSE; TRANSFORMATION; MALIGNANCIES; PATHOGENESIS; RAPAMYCIN; PROPOSAL;

D O I：

10.1038/modpathol.2008.148

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The assembly of a collection of gene-expression signatures of the major types of B-cell non-Hodgkin's lymphoma has identified increased T-cell leukemia/lymphoma 1A (TCL1) expression in multiple lymphoma types and cases, and has enabled the investigation of the functional and clinical importance of TCL1 expression. Specifically, Burkitt's lymphoma cases show a homogeneously strong expression of TCL1, whereas diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia, nodal marginal zone lymphoma, and splenic marginal zone lymphoma display a striking variability in the intensity of TCL1 staining. This was validated in two independent series. A Gene-Set Enrichment Analysis of the genes correlated with TCL1A expression found that variation in the level of expression of TCL1A was significantly associated with some of the most important gene signatures recognizing B-cell lymphoma pathogenesis and heterogeneity, such as germinal center, B-cell receptor, NF-kappa B (and its target genes), death, MAP kinases, TNFR1, TOLL, and IL1R. Additionally, TCL1 expression was correlated with shorter time to treatment in chronic lymphocytic leukemia cases and shorter lymphoma-specific survival in mantle cell lymphoma series, thus indicating the clinical and biological significance of TCL1 expression, and suggesting TCL1A as a potential therapeutic target.

引用

页码：206 / 215

页数：10

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