Combined Therapy With a Calcium Channel Blocker and an Angiotensin II Type 1 Receptor Blocker

被引：32

作者：

Bakris, George L. ^{[1
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2008年 / 10卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1111/j.1524-6175.2007.08029.x

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Fixed-dosed combination regimens consisting of a calcium channel blocker and an angiotensin II type 1 receptor blocker represent a new addition to the available antihypertensive treatment options. Clinical trials demonstrate that both the dihydropyridine calcium channel blocker amlodipine and angiotensin II receptor blockers are effective agents for the management of hypertension in individuals with or without cardiovascular disease. When combined, these 2 classes of agents have complementary effects on blood pressure, as each targets separate signaling pathways in the vasculature pivotal to the regulation of vascular function. In clinical trials this combination has demonstrated better efficacy, defined by time to reach blood pressure targets as well as levels of blood pressure achieved, compared with the individual agents. In a comparative trial, a combination of amlodipine plus valsartan (an angiotensin II receptor blocker) also produced greater reductions in blood pressure compared with a combination of lisinopril (an angiotensin-converting enzyme inhibitor) and hydrochlorothiazide . The combination of amlodipine and an angiotensin II receptor blocker is well tolerated, including in patients with stage 2 hypertension and the elderly. (J Clin Hypertens (Greenwich). 2008;10(1 suppl 1):27-32) (C) 2008 Le Jacq

引用

页码：27 / 32

页数：6

共 37 条

[1]

Bakris George L, 2003, J Clin Hypertens (Greenwich), V5, P202, DOI 10.1111/j.1524-6175.2002.2041.x

[2] Vascular inflammation and the renin-angiotensin system [J].

Brasier, AR ;

Recinos, A ;

Eledrisi, MS .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (08) :1257-1266

[3]

Cheung Bernard M Y, 2006, J Clin Hypertens (Greenwich), V8, P93, DOI 10.1111/j.1524-6175.2006.04895.x

[4] Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [J].

Chobanian, AV ;

Bakris, GL ;

Black, HR ;

Cushman, WC ;

Green, LA ;

Izzo, JL ;

Jones, DW ;

Materson, BJ ;

Oparil, S ;

Wright, JT ;

Roccella, EJ .

HYPERTENSION, 2003, 42 (06) :1206-1252

[5]

CHRYSANT SG, 2007, J CLIN HYPERTENS, V9, P486

[6] Rationale and design for the blood pressure intervention of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial [J].

Cushman, William C. ;

Grimm, Richard H., Jr. ;

Cutler, Jeffrey A. ;

Evans, Gregory W. ;

Capes, Sarah ;

Corson, Marshall A. ;

Sadler, Laurie S. ;

Alderman, Michael H. ;

Peterson, Kevin ;

Bertoni, Alain ;

Basile, Jan N. .

AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (12A) :44I-55I

[7] Protective effects of angiotensin II interruption: Evidence for antiinflammatory actions [J].

Dagenais, NJ ;

Jamali, F .

PHARMACOTHERAPY, 2005, 25 (09) :1213-1229

[8] Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE):: a randomised trial against atenolol [J].

Dahlöf, B ;

Devereux, RB ;

Kjeldsen, SE ;

Julius, S ;

Beevers, G ;

de Faire, U ;

Fyhrquist, F ;

Ibsen, H ;

Kristiansson, K ;

Lederballe-Pedersen, O ;

Lindholm, LH ;

Nieminen, MS ;

Omvik, P ;

Oparil, S ;

Wedel, H .

LANCET, 2002, 359 (9311) :995-1003

[9] Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA):: a multicentre randomised controlled trial [J].

Dahlöf, B ;

Sever, PS ;

Poulter, NR ;

Wedel, H ;

Beevers, DG ;

Caulfield, M ;

Collins, R ;

Kjeldsen, SE ;

Kristinsson, A ;

McInnes, GT ;

Mehlsen, J ;

Nieminen, M ;

O'Brien, E ;

Östergren, J .

LANCET, 2005, 366 (9489) :895-906

[10] Adherence patterns among patients treated with fixed-dose combination versus separate antihypertensive agents [J].

Gerbino, Philip P. ;

Shoheiber, Omar .

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2007, 64 (12) :1279-1283

← 1 2 3 4 →