Expression of pTα mRNA in a committed dendritic cell precursor in the human thymus

被引：111

作者：

Res, PCM ^{[1
]}

Couwenberg, F ^{[1
]}

Vyth-Dreese, FA ^{[1
]}

Spits, H ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Immunol, Antoni Van Leeuwenhoek Huis, NL-1066 CX Amsterdam, Netherlands

来源：

BLOOD | 1999年 / 94卷 / 08期

关键词：

D O I：

10.1182/blood.V94.8.2647.420k06_2647_2657

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have characterized dendritic cell precursors (pre-DC) in the human thymus. These CD1a(-)CD3(-)CD4(+)CD8(-) cells express high levels of interleukin-3R alpha (IL-3R alpha) on the membrane and are able to develop into mature DC upon culture with IL-3 and CD40 ligation. The DC precursors are predominantly located in the thymic medulla. Interestingly, the pre-DC express pT alpha mRNA, which is also present in CD1a(+)CD3(-)CD4(+) CD8(-) pre-T cells. Yet, the pre-DC jack expression of recombination activating gene-1 mRNA and fail to develop into T cells in appropriate assays. The thymic pre-DC are very similar to the recently characterized pre-DC found in the T cell areas of the tonsil, and it is suggested that these pre-DC populations are of lymphoid origin. (C) 1999 by The American Society of Hematology.

引用

页码：2647 / 2657

页数：11

共 28 条

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