Parallel fluorous biphasic synthesis of 3H-quinazolin-4-ones by an Aza-Wittig reaction employing perfluoroalkyl-tagged triphenylphosphine

被引：29

作者：

Barthélémy, S ^{[1
]}

Schneider, S ^{[1
]}

Bannwarth, W ^{[1
]}

机构：

[1] Univ Freiburg, Inst Organ Chem & Biochem, D-79104 Freiburg, Germany

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 05期

关键词：

fluorous biphasic system; Aza-Wittig; perfluoro-tagged phosphine; 3H-quinazolin-4-ones;

D O I：

10.1016/S0040-4039(01)02279-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A perfluoroalkyl-tagged triphenylphosphine eras applied in a fluorous biphasic system for the efficient parallel synthesis of 3H-quinazolin-4-ones via an Aza-Wittig reaction. The products were isolated by solid-phase extraction on fluorous reversed-phase silica gel. A new solid-phase bound phosphine derivative was used for comparison and yielded similar results. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：807 / 810

页数：4