NMR-based model of an ecteinascidin 743-DNA adduct

被引：89

作者：

Moore, BM ^{[1
]}

Seaman, FC ^{[1
]}

Hurley, LH ^{[1
]}

机构：

[1] UNIV TEXAS,COLL PHARM,DRUG DYNAM INST,AUSTIN,TX 78712

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 119卷 / 23期

关键词：

D O I：

10.1021/ja9704500

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

收藏

页码：5475 / 5476

页数：2

相关论文

共 12 条

[1] CHARACTERIZATION OF A UNIQUE TOMAYMYCIN-D(CICGAATTCICG)2 ADDUCT CONTAINING 2 DRUG MOLECULES PER DUPLEX BY NMR, FLUORESCENCE, AND MOLECULAR MODELING STUDIES [J].

BOYD, FL ;

STEWART, D ;

REMERS, WA ;

BARKLEY, MD ;

HURLEY, LH .

BIOCHEMISTRY, 1990, 29 (09) :2387-2403

[2]

BOYD FL, UNPUB

[3] Enantioselective total synthesis of ecteinascidin 743 [J].

Corey, EJ ;

Gin, DY ;

Kania, RS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (38) :9202-9203

[4]

GAIT MJ, 1984, OLIGONUCLEOTIDE SYNT

[5]

GUAN Y, 1993, J BIOMOL STRUCT DYN, V10, P793

[6] ASSIGNMENT OF THE NON-EXCHANGEABLE PROTON RESONANCES OF D(C-G-C-G-A-A-T-T-C-G-C-G) USING TWO-DIMENSIONAL NUCLEAR MAGNETIC-RESONANCE METHODS [J].

HARE, DR ;

WEMMER, DE ;

CHOU, SH ;

DROBNY, G ;

REID, BR .

JOURNAL OF MOLECULAR BIOLOGY, 1983, 171 (03) :319-336

[7]

PEARLMAN DA, 1995, AMBER 4 1

[8] DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidin turbinata [J].

Pommier, Y ;

Kohlhagen, G ;

Bailly, C ;

Waring, M ;

Mazumder, A ;

Kohn, KW .

BIOCHEMISTRY, 1996, 35 (41) :13303-13309

[9]

Remers W.A., 1995, CANC CHEMOTHERAPEUTI, P577

[10] ECTEINASCIDIN-729, ECTEINASCIDIN-743, ECTEINASCIDIN-745, ECTEINASCIDIN-759A, ECTEINASCIDIN-759B, AND ECTEINASCIDIN-770 - POTENT ANTITUMOR AGENTS FROM THE CARIBBEAN TUNICATE ECTEINASCIDIA-TURBINATA [J].

RINEHART, KL ;

HOLT, TG ;

FREGEAU, NL ;

STROH, JG ;

KEIFER, PA ;

SUN, F ;

LI, LH ;

MARTIN, DG .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (15) :4512-4515