New insights into the redox chemistry of ruthenium metallopharmaceuticals:: The electrochemical behaviour of [LH][trans-RuIIICl4L2] (L = imidazole or indazole) complexes

被引：10

作者：

Ravera, M ^{[1
]}

Cassino, C ^{[1
]}

Baracco, S ^{[1
]}

Osella, D ^{[1
]}

机构：

[1] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci Ambiente & Vita, I-15100 Alessandria, Italy

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2006年 / 04期

关键词：

antitumor agents; electrochemistry; redox chemistry; ruthenium;

D O I：

10.1002/ejic.200500634

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Here we report the findings from a study on the electrochemical behaviour of two Ru-III complexes [LH][trans-(RuCl4L2)-Cl-III] (L = imidazole, ICR, or indazole, IndCR) in aqueous solution at different pH values. An electrochemically reversible and chemically quasi-reversible one-electron reduction is observed for both compounds. Despite the similarity of the structures, the fate of the electrogenerated Ru-II species is different; in the case of ICR, imidazole, followed by a chloride ion, is released as the consequence of the reduction, while for IndCR two subsequent water for chloride substitutions take place. Our measurements suggests that the Ru-III complexes under study may serve as pro-drugs, being activated by reduction in a suitable aqueous environment and, therefore, binding biomolecules more rapidly. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006.

引用

页码：740 / 746

页数：7

共 22 条

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