Highly enantioselective Aza-Baylis-Hillman reaction in a chiral reaction medium

被引：160

作者：

Gausepohl, Rolf

Buskens, Pascal

Kleinen, Jochen

Bruckmann, Angelika

Lehmann, Christian W.

Klankermayer, Jurgen

Leitner, Walter

机构：

[1] Rhein Westfal TH Aachen Klinikum, Inst Tech & Makromol Chem, D-52074 Aachen, Germany

[2] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 22期

关键词：

asymmetric synthesis; C-C coupling; chiral solvents; ionic liquids; organocatalysis;

D O I：

10.1002/anie.200600327

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Let's twist again! The first highly enantioselective asymmetric reaction in which a chiral reaction medium is the sole source of chirality is presented. The aza-Baylis-Hillman reaction in an ionic liquid with a chiral anion, whose design is based on mechanistic insights, gave products with up to M% ee. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3689 / 3692

页数：4

共 29 条

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[Anonymous], ANGEW CHEM

[2] Chiral quinuclidine-based amine catalysts for the asymmetric one-pot, three-component aza-Baylis-Hillman reaction [J].