Emerging Chagas disease in Amazonian Brazil

被引：211

作者：

Coura, JR ^{[1
]}

Junqueira, ACV

Fernandes, O

Valente, SAS

Miles, MA

机构：

[1] Inst Oswaldo Cruz, Dept Trop Med, BR-20001 Rio De Janeiro, Brazil

[2] Fdn Nacl Saude, Inst Evandro Chagas, Belem, Para, Brazil

[3] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

来源：

TRENDS IN PARASITOLOGY | 2002年 / 18卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1471-4922(01)02200-0

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In the Amazon Basin, Trypanosoma cruzi infection is enzootic, involving a variety of wild mammals and at least 10 of the 16 reported silvatic triatomine bug species. Human cases of Chagas disease are increasing, indicating that the disease may be emerging as a wider public health problem in the region: 38 cases from 1969 to 1992, and 167 in the past eight years. This article reviews the status of Chagas disease in Amazonian Brazil, including known reservoirs and vectors, and the genetic diversity of T cruzi. At least three subspecific groups of T. cruzi-T. cruzil Z1, T. cruzi Z3 and T.cruzi Z3/Z1 ASAT- are present. It appears that T cruzil has an extant capacity for genetic exchange. Attention is also drawn to the risk of domestic endemicity, in addition to the tasks facing the disease control authorities.

引用

页码：171 / 176

页数：6

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