Long-term reprogramming of the innate immune system

被引：127

作者：

Dominguez-Andres, Jorge ^{[1
,2
]}

Netea, Mihai G. ^{[1
,2
,3
,4
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Geert Grootepl 8, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis RCI, Geert Grootepl 8, NL-6500 HB Nijmegen, Netherlands

[3] Univ Bonn, Dept Genom & Immunoregulat, Life & Med Sci Inst LIMES, Bonn, Germany

[4] Craiova Univ Med & Pharm, Human Genom Lab, Craiova, Romania

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2019年 / 105卷 / 02期

关键词：

Innate immune system; trained immunity; metabolism; epigenetics; reprogramming; inflammation; vaccination; atherosclerosis; sepsis; cancer; BCG VACCINATION; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; GLUCOSE-METABOLISM; DISEASE TOLERANCE; ENERGY-METABOLISM; TRAINED IMMUNITY; BLADDER-CANCER; LIFE-SPAN; INFLAMMATION; CELLS;

D O I：

10.1002/JLB.MR0318-104R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

During the last few years, a growing body of evidence has shown that immunological memory is not an exclusive trait of lymphocytes, as many inflammatory insults can alter the functionality and the responsiveness of the innate immune system in the long term. Innate immune cells, such as monocytes, macrophages, dendritic cells, and NK cells can be influenced by the encounters with inflammatory stimuli, undergoing functional reprogramming and developing changed responses to subsequent chellenges. The long-term reprogramming depends on the rewiring of cell metabolism and epigenetic processes, and they stay at the basis of induction of both innate immune memory (also termed trained immunity) and innate immune tolerance. Here, we review the central role that the effects of this long-term reprogramming of innate immune cells plays in a number of clinically relevant conditions such as vaccination, atherosclerosis, sepsis, and cancer.

引用

页码：329 / 338

页数：10

共 119 条

[1]

Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? [J].

Aaby, Peter ;

Roth, Adam ;

Ravn, Henrik ;

Napirna, Bitiguida Mutna ;

Rodrigues, Amabelia ;

Lisse, Ida Maria ;

Stensballe, Lone ;

Diness, Birgitte Rode ;

Lausch, Karen Rokkedal ;

Lund, Najaaraq ;

Biering-Sorensen, Sofie ;

Whittle, Hilton ;

Benn, Christine Stabell .

JOURNAL OF INFECTIOUS DISEASES, 2011, 204 (02) :245-252

[2]

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity [J].

Arts, Rob J. W. ;

Moorlag, Simone J. C. F. M. ;

Novakovic, Boris ;

Li, Yang ;

Wang, Shuang-Yin ;

Oosting, Marije ;

Kumar, Vinod ;

Xavier, Ramnik J. ;

Wijmenga, Cisca ;

Joosten, Leo A. B. ;

Reusken, Chantal B. E. M. ;

Benn, Christine S. ;

Aaby, Peter ;

Koopmans, Marion P. ;

Stunnenberg, Hendrik G. ;

van Crevel, Reinout ;

Netea, Mihai G. .

CELL HOST & MICROBE, 2018, 23 (01) :89-+

[3]

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity [J].

Arts, Rob J. W. ;

Novakovic, Boris ;

ter Horst, Rob ;

Carvalho, Agostinho ;

Bekkering, Siroon ;

Lachmandas, Ekta ;

Rodrigues, Fernando ;

Silvestre, Ricardo ;

Cheng, Shih-Chin ;

Wang, Shuang-Yin ;

Habibi, Ehsan ;

Goncalves, Luis G. ;

Mesquita, Ines ;

Cunha, Cristina ;

van Laarhoven, Arjan ;

van de Veerdonk, Frank L. ;

Williams, David L. ;

van der Meer, Jos W. M. ;

Logie, Colin ;

O'Neill, Luke A. ;

Dinarello, Charles A. ;

Riksen, Niels P. ;

van Crevel, Reinout ;

Clish, Clary ;

Notebaart, Richard A. ;

Joosten, Leo A. B. ;

Stunnenberg, Hendrik G. ;

Xavier, Ramnik J. ;

Netea, Mihai G. .

CELL METABOLISM, 2016, 24 (06) :807-819

[4]

Immunometabolic Pathways in BCG-Induced Trained Immunity [J].

Arts, Rob J. W. ;

Carvalho, Agostinho ;

La Rocca, Claudia ;

Palma, Carla ;

Rodrigues, Fernando ;

Silvestre, Ricardo ;

Kleinnijenhuis, Johanneke ;

Lachmandas, Ekta ;

Goncalves, Luis G. ;

Belinha, Ana ;

Cunha, Cristina ;

Oosting, Marije ;

Joosten, Leo A. B. ;

Matarese, Giuseppe ;

van Crevel, Reinout ;

Netea, Mihai G. .

CELL REPORTS, 2016, 17 (10) :2562-2571

[5]

Srebp-controlled glucose metabolism is essential for NK cell functional responses [J].

Assmann, Nadine ;

O'Brien, Katie L. ;

Donnelly, Raymond P. ;

Dyck, Lydia ;

Zaiatz-Bittencourt, Vanessa ;

Loftus, Roisin M. ;

Heinrich, Paul ;

Oefner, Peter J. ;

Lynch, Lydia ;

Gardiner, Clair M. ;

Dettmer, Katja ;

Finlay, David K. .

NATURE IMMUNOLOGY, 2017, 18 (11) :1197-+

[6]

Bambouskova M, 2018, NATURE, V1

[7]

Metabolic Induction of Trained Immunity through the Mevalonate Pathway [J].

Bekkering, Siroon ;

Arts, Rob J. W. ;

Novakovic, Boris ;

Kourtzelis, Ioannis ;

van der Heijden, Charlotte D. C. C. ;

Li, Yang ;

Popa, Calin D. ;

ter Horst, Rob ;

van Tuijl, Julia ;

Netea-Maier, Romana T. ;

de Veerdonk, Frank L. van ;

Chavakis, Triantafyllos ;

Joosten, Leo A. B. ;

van der Meer, Jos W. M. ;

Stunnenberg, Henk ;

Riksen, Niels P. ;

Netea, Mihai G. .

CELL, 2018, 172 (1-2) :135-+

[8]

In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes [J].

Bekkering, Siroon ;

Blok, Bastiaan A. ;

Joosten, Leo A. B. ;

Riksen, Niels P. ;

van Crevel, Reinout ;

Netea, Mihai G. .

CLINICAL AND VACCINE IMMUNOLOGY, 2016, 23 (12) :926-933

[9]

Non-specific Effects of Vaccines and Stunting: Timing May Be Essential [J].

Berendsen, Mike L. T. ;

Smits, Jeroen ;

Netea, Mihai G. ;

van der Ven, Andre .

EBIOMEDICINE, 2016, 8 :341-348

[10]

Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines [J].

Blok, Bastiaan A. ;

Arts, Rob J. W. ;

van Crevel, Reinout ;

Benn, Christine Stabell ;

Netea, Mihai G. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2015, 98 (03) :347-356

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