Does complement play a role in bone development and regeneration?

被引：66

作者：

Schoengraf, Philipp ^{[1
]}

Lambris, John D. ^{[2
]}

Recknagel, Stefan ^{[1
]}

Kreja, Ludwika ^{[1
]}

Liedert, Astrid ^{[1
]}

Brenner, Rolf E. ^{[4
]}

Huber-Lang, Markus ^{[3
]}

Ignatius, Anita ^{[1
]}

机构：

[1] Univ Ulm, Ctr Muskuloskelettal Res, Inst Orthopaed Res & Biomech, D-89081 Ulm, Germany

[2] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[3] Univ Ulm, Ctr Musculoskeletal Res Ulm, Dept Orthopaed, Div Joint & Connect Tissue Dis, D-89081 Ulm, Germany

[4] Univ Ulm, Ctr Musculoskeletal Res Ulm, Ctr Surg, Dept Traumatol Hand Plast & Reconstruct Surg, D-89075 Ulm, Germany

来源：

IMMUNOBIOLOGY | 2013年 / 218卷 / 01期

关键词：

Bone; Complement; Inflammation; Mesenchymal stem cells; Osteoblasts; Osteoclasts; PERIPHERAL-BLOOD LEUKOCYTES; PROTEIN-COUPLED RECEPTORS; MESENCHYMAL STEM-CELLS; BLUNT CHEST TRAUMA; 3RD COMPONENT; OSTEOCLAST DIFFERENTIATION; OSTEOBLASTIC CELLS; STROMAL CELLS; IN-VITRO; ENDOCHONDRAL OSSIFICATION;

D O I：

10.1016/j.imbio.2012.01.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The skeletal and the immune system are not two independent systems, rather, there are multifaceted and complex interactions between the different cell types of both systems and there are several shared cytokines. As a part of the innate immunity, the complement system was found to be an important link between bone and immunity. Complement proteins appear to be involved in bone development and homeostasis, and specifically influence osteoblast and osteoclast activity. This review describes the complex mutual regulation of the two systems, and indicates some of the negative side effects as a result of inappropriate or excessive complement activation. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：1 / 9

页数：9

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