Chitosan/alginate complexes for vaginal delivery of chlorhexidine digluconate

被引：74

作者：

Abruzzo, A. ^{[1
]}

Bigucci, F. ^{[1
]}

Cerchiara, T. ^{[1
]}

Saladini, B. ^{[2
]}

Gallucci, M. C. ^{[3
]}

Cruciani, F. ^{[1
]}

Vitali, B. ^{[1
]}

Luppi, B. ^{[1
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40127 Bologna, Italy

[2] PolyCrystalLine Srl, I-40059 Bologna, Italy

[3] Univ Calabria, Dept Chem, I-87036 Cosenza, Italy

来源：

CARBOHYDRATE POLYMERS | 2013年 / 91卷 / 02期

关键词：

Chitosan/alginate complex; Chlorhexidine digluconate; Vaginal delivery; Mucoadhesive inserts; DRUG-DELIVERY; POLYELECTROLYTE COMPLEXES; NASAL INSERTS; CHITOSAN; MUCOADHESIVE; HYDROGELS; CHITIN;

D O I：

10.1016/j.carbpol.2012.08.074

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Chitosan/alginate complexes were prepared at different polycation/polyanion molar ratios and freeze-dried vaginal inserts were obtained for chlorhexidine digluconate local delivery in genital infections. Complex yield, FT-IR spectra, and TGA thermograms were studied to confirm the interaction between the two polyions. The influence of different complexes on physical handling, morphology, and drug distribution in the samples were evaluated by friability test, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS), respectively. In vitro water-uptake, mucoadhesion and release tests were performed as well as microbiological tests toward pathogenic vaginal microorganisms. The results showed that the selection of suitable chitosan/alginate molar ratio and drug loading allowed modulate insert ability to hydrate, adhere to the mucosa, and release chlorhexidine digluconate. The insert containing an excess of alginate was found to be the best performing formulation and showed good antimicrobial activity toward the pathogens Candida albicans and Escherichia coli. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：651 / 658

页数：8

共 40 条

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[2]

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