Multifunctional near-infrared fluorescent nanoclusters for simultaneous targeted cancer imaging and photodynamic therapy

被引：23

作者：

Ai, Jun ^{[1
,3
]}

Li, Jing ^{[3
]}

Ga, Lu ^{[2
]}

Yun, Guohong ^{[1
]}

Xu, Li ^{[3
]}

Wang, Erkang ^{[3
]}

机构：

[1] Inner Mongolia Normal Univ, Coll Chem & Environm Sci, Hohhot 010022, Peoples R China

[2] Inner Mongolia Med Univ, Coll Pharm, Jinchuankaifaqu 010110, Hohhot, Peoples R China

[3] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 222卷

基金：

中国国家自然科学基金;

关键词：

Silver nanoclusters; NIR; DNA aptamer; Cancer imaging; PDT; SILVER NANOCLUSTERS; APTAMER; PROTEIN; NANOPARTICLE; CELLS;

D O I：

10.1016/j.snb.2015.09.026

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

In this paper, the water-soluble DNA encapsulated silver nanoclusters with near-infrared (NIR) fluorescence were prepared, which can be used for the simultaneous targeted cancer imaging and enhanced photothermal therapy (PTT) or photodynamic therapy (PDT) due to the synergistic effects between the photodynamic agent and NIR silver nanoclusters. AS1411 was rationally connected with DNA scaffold of the silver nanoclusters and retained its secondary structure to load photosensitizer efficiently. The binding affinity of AS1411 to the nucleolin with high fluorescence of silver nanoclusters provided opportunities for their application in the intracellular imaging and nuclear staining. Meanwhile, the PPIX (Protoporphyrin IX) can also be captured by AS1411 to yield the multifunctional nanoconjugates (MFNACs), which can be used for the cancer therapy under irradiation of light. More interesting, enhanced photodynamic efficiency toward the colon cancer cells was achieved based on the synergetic effect of PDT of PPIX and photothermal therapy of NIR fluorescent probe. (C) 2015 Published by Elsevier B.V.

引用

页码：918 / 922

页数：5

共 19 条

[1]

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer [J].