Neuropeptide Y-induced angiogenesis in aging

被引：50

作者：

Kitlinska, J ^{[1
]}

Lee, EW ^{[1
]}

Movafagh, S ^{[1
]}

Pons, J ^{[1
]}

Zukowska, Z ^{[1
]}

机构：

[1] Georgetown Univ, Med Ctr, Dept Physiol & Biophys, Washington, DC 20007 USA

来源：

PEPTIDES | 2002年 / 23卷 / 01期

关键词：

neuropeptide Y; angiogenesis; aging;

D O I：

10.1016/S0196-9781(01)00581-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays, NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed reduced expression (RT-PCR) of Y2 receptors and the NPY converting enzyme, dipeptidyl peptidase IV (DPPIV), in spleens. Aging of human microvascular endothelial cells in vitro led to a loss of their mitogenic responses to NPY accompanied by a lack of NPY receptor mRNAs. Thus, NPY-dependent angiogenesis is impaired with age, which is associated with a decreased expression of endothelial NPY receptors (Y2) and DPPIV. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：71 / 77

页数：7

共 41 条

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Growth factors reverse the impaired sprouting of microvessels from aged mice [J].