The next wave:: Protein tyrosine phosphatases enter T cell antigen receptor signalling

被引：24

作者：

Mustelin, T ^{[1
]}

Brockdorff, J ^{[1
]}

Rudbeck, L ^{[1
]}

Gjörloff-Wingren, A ^{[1
]}

Han, SL ^{[1
]}

Wang, XD ^{[1
]}

Tailor, P ^{[1
]}

Saxena, M ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA

来源：

CELLULAR SIGNALLING | 1999年 / 11卷 / 09期

关键词：

protein tyrosine phosphatases; T cell activation; T cell antigen receptor; protein tyrosine kinases; T lymphocytes;

D O I：

10.1016/S0898-6568(99)00016-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent years have seen an exponentially increasing interest in the molecular mechanisms of signal transduction. Much of the focus has been on protein tyrosine kinase-mediated signalling, while the study of protein tyrosine phosphatases has lagged behind. We predict that the phosphatases will become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the-art in our understanding of the structure, regulation and role of protein tyrosine phosphatases in T lymphocyte activation. (C) 1999 Elsevier Science Inc.

引用

页码：637 / 650

页数：14

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