Effect of diabetes on renal medullary oxygenation during water diuresis

被引:86
作者
Epstein, FH
Veves, A
Prasad, PV
机构
[1] Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Dept Med, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Dept Radiol, Boston, MA 02215 USA
关键词
D O I
10.2337/diacare.25.3.575
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE- To study the effect of water diuresis on renal medullary and cortical oxygenation in patients with diabetes using blood oxygenation level-dependent magnetic resonance imaging (BOLD MRI). RESEARCH DESIGN AND METHODS- Nine mild diabetic subjects (48 +/- 2.7 years of age, six women) and nine nondiabetic subjects of similar age and sex, all without known vascular or renal disease, were studied noninvasively by MRI before and during water diuresis. RESULTS- Water diuresis induced an increase in medullary oxygenation in control subjects, producing a decrease in R-2* (apparent spin-spin relaxation time) of 1.89 +/- 0.27 (P < 0.01), but no significant change in the group of diabetic subjects. CONCLUSIONS- These findings in middle-aged diabetic subjects, which resembled those previously described in elderly subjects >65 years of age, suggest early impairment of adaptive vasodilatation within the renal medulla in diabetes.
引用
收藏
页码:575 / 578
页数:4
相关论文
共 12 条
[1]   MECHANISMS OF DISEASE - HYPOXIA OF THE RENAL MEDULLA - ITS IMPLICATIONS FOR DISEASE [J].
BREZIS, M ;
ROSEN, S .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (10) :647-655
[2]   THE PATHOPHYSIOLOGICAL IMPLICATIONS OF MEDULLARY HYPOXIA [J].
BREZIS, M ;
ROSEN, SN ;
EPSTEIN, FH .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1989, 13 (03) :253-258
[3]   Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes [J].
Caballero, AE ;
Arora, S ;
Saouaf, R ;
Lim, SC ;
Smakowski, P ;
Park, JY ;
King, GL ;
LoGerfo, FW ;
Horton, ES ;
Veves, A .
DIABETES, 1999, 48 (09) :1856-1862
[4]  
Granger DL, 1996, METHOD ENZYMOL, V268, P142
[5]   BIOSYNTHESIS AND METABOLISM OF ENDOTHELIUM-DERIVED NITRIC-OXIDE [J].
IGNARRO, LJ .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1990, 30 :535-560
[6]   IMPAIRED ENDOTHELIUM-DEPENDENT VASODILATION IN PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].
JOHNSTONE, MT ;
CREAGER, SJ ;
SCALES, KM ;
CUSCO, JA ;
LEE, BK ;
CREAGER, MA .
CIRCULATION, 1993, 88 (06) :2510-2516
[7]   RADIOCONTRAST-ASSOCIATED RENAL DYSFUNCTION - INCIDENCE AND RISK-FACTORS [J].
LAUTIN, EM ;
FREEMAN, NJ ;
SCHOENFELD, AH ;
BAKAL, CW ;
HARAMATI, N ;
FRIEDMAN, AC ;
LAUTIN, JL ;
BRAHA, S ;
KADISH, EG ;
SPRAYREGEN, S ;
BELIZON, I .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1991, 157 (01) :49-58
[8]   Acute renal failure after coronary intervention: Incidence, risk factors, and relationship to mortality [J].
McCullough, PA ;
Wolyn, R ;
Rocher, LL ;
Levin, RN ;
ONeill, WW .
AMERICAN JOURNAL OF MEDICINE, 1997, 103 (05) :368-375
[9]   Changes in renal medullary pO2 during water diuresis as evaluated by blood oxygenation level-dependent magnetic resonance imaging:: Effects of aging and cyclooxygenase inhibition [J].
Prasad, PV ;
Epstein, FH .
KIDNEY INTERNATIONAL, 1999, 55 (01) :294-298
[10]   Breath-hold R2* mapping with a multiple gradient-recalled echo sequence: Application to the evaluation of intrarenal oxygenation [J].
Prasad, PV ;
Chen, Q ;
Goldfarb, JW ;
Epstein, FH ;
Edelman, RR .
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1997, 7 (06) :1163-1165